Summary
Nineteen DSM-III-R schizophrenic patients and 15 normal subjects, matched for sex and age, were evaluated according to their clinical and corpus callosum structural characteristics. They were evaluated on their size of callosum by means of Magnetic Resonance Imaging. Neither diagnosis nor sex significantly affects corpus callosum indices. Statistical analysis evidentiates a relationship between DSM-III-R axis-V scores and corpus callosum length in schizophrenics, and between age at onset of the illness and corpus callosum length in schizophrenics.
Similar content being viewed by others
References
American Psychiatric Association (1987) DSM-III-R: Diagnostic and statistical manual of mental disorders. 3rd ed revied. Washington, DC, APA
Andreasen NC (1989) Nuclear magnetic resonance imaging. In: Andreasen NC (ed): Brain imaging: applications in psychiatry. Washington, DC, American Psychiatric Press, pp 55–88
Bigelow LB, Nasrallah HA, Rauscher FP (1983) Corpus callosum thickness in chronic schizophrenia. Br J Psychiatry 142: 284–287
Casanova MS, Sanders RD, Goldberg TE, Bigelow LB, Christian G, Torrey EF, Weinberger DR (1990) Morphometry of the corpus callosum in monozygotic twins discordant for schizophrenia: a magnetic resonance imaging study. J Neurol Neurosurg Psychiatry 54:416–412
David AS, Wacharasindhu A, Lishman WA (1993) Severe psychiatric disturbances and abnormalities of the corpus callosum: review and case series. J Neurol Neurosurg Psychiatry 56(1): 85–93
De Lacoste-Utamsing C, Holloway RL (1982) Sexual dimorphism in the human corpus callosum. Science 216:1431–1432
Flor-Henry P (1979) Commentary on the cortical issues and neuropsychological and electroencephalographic findings. In: Gruzelier T, Flor-Henry P (eds). Hemisphere asymmetries of function in psychopathology. Elsevier/North Holland Biomedical Press, Amsterdam, pp 341–362
Flor-Henry P, Fromm-Auch D, Schopflocher D (1983) Neuropsychological dimension in psychopathology. In: Flor-Henry P, Gruzelier J (eds): Laterality and psychopathology: Elsevier, Amsterdam, pp 59–81
Georgy BA, Hesselink JR, Jernigan TL (1993) MR imaging of the corpus callosum. Am J Roentgenol 160(5):949–955
Gunther W, Petsch R, Steinberg R, Moser E, Streck P, Heller H, Kurtz G, Hippius H (1991) Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and magnetic resonance imaging. Biol Psychiatry 29:535–555
Gur RE, Resnick SM, Alavi A (1987) Regional brain function in schizophrenia: positron emission tomography study. Arch Gen Psychiatry 44:119–125
Kelsoe JR, Cadet JL, Pickar D, Weinberger DR (1988) Quantitative neuroanatomy in schizophrenia: a controlled magnetic resonance imaging study. Arch Gen Psychiatry 45:533–541
Kendell RE (1983) Schizophrenia. In: Kendell RE, Zealley AK (eds): Companion to psychiatric studies. 3rd ed. Churchill Livingstone, New York, pp 275–296
Kishimoto H, Kuwahara H, Takazu O, Ohno S, Hama Y, Sato C, Ishii T, Nomura Y, Fujita H, Miyauchi T, Yokoi S, Iio M (1987) The three subtypes of chronic schizophrenia using 11-C-glucose positron emission tomography (PET). Psychiatry Res 21:285–292
Lehmann HE, Cancro R (1990) Schizophrenia: clinical features. In: Kaplan HI, Sadock BJ (eds): Comprehensive textbook of psychiatry, vol 1, 5th ed. Williams and Wilkins, Baltimore, pp 680–713
McGlone J, Fox AJ (1982) Evidence from sidum amytal studies of greater asymmetry of verbral representation in men compared to women. In: Akimoto H, Kazamatsuri H, Seino M, Ward A (eds): Advances in Epileptology: XIIIth Epilepsy International Symposium. Raven Press, New York
Potter SM, Graves RE (1988) Is interhemispheric transfer related to handedness and gender? Neuropsychologia 26:319–325
Raczkowski D, Kalat JW, Nebes R (1974) Reliability and validity of some handedness questionnaire items. Neuropsychologia 12:43–48
Raine A, Harrison GN, Reynolds GP, Sheard C, Cooper JE, Meddley I (1990) Structural and functional characteristics of the corpus callosum in schizophrenics, psychiatric controls, and normal controls. Arch Gen Psychiatry 47:1060–1064
Robins LN, Helzer J, Cottler L, Goldring E (1989) NIMH Diagnostic Interview Schedule. Version III-R (DIS-III-R) Washington University School of Medicine, St. Louis
Rosenthal and Bigelow (1972) Quantitative brain measurements in chronic schizophrenia. Br J Psychiatry 121:259–264
Rossi A, Stratta P, Gallucci M, Passariello R, Casacchia M (1988) Brain morphology in schizophrenia by magnetic resonance imaging (MRI). Acta Psychiatr Scand 77:741–745
Rossi A, Stratta P, Gallucci M, Passariello R, Casacchia M (1989) Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: a pilot study. Am J Psychiatry 146:99–101
Smith RC, Tamminga CA (1985) Brain imaging in psychiatry: new developments. Psychopharmacol Bull 21:588–594
Smith RC, Baumgartner R, Calderon M (1987) Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Res 20:33–46
Statistical Package for Social Sciences (SPSS) (1986) McGraw-Hill, Chicago, Illinois
Stevens JR, Bigelow L, Denney D, Lipkin, J, Livermore AH, Rauscher F, Wyatt RJ (1979) Telemetered EEG-EOG during psychotic behaviors of schizophrenia. Arch Gen Psychiatry 36:251–262
Tsuang MT, Lyons MJ, Faraone SV (1990) Heterogeneity of schizophrenia. Conceptual models and analytic strategies. Br J Psychiatry 156:17–26
Uematsu M, Kaiya H (1988) The morphology of the corpus callosum in schizophrenia: an MRI study. Schizophr Res 1 391–398
Witelson SF (1989) Hand and sex differences in the isthmus and genu of the human corpus callosum. A postmortem morphological study. Brain 112:799–835
Woodruff PW, Pearlson GD, Geer MJ, Barta PE, Chilcoat HD (1993) A computerized magnetic resonance imaging study of corpus callosum morphology in schizophrenia. Psychol Med 23(1):45–56
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Colombo, C., Bonfanti, A. & Scarone, S. Anatomical characteristics of the corpus callosum and clinical correlates in schizophrenia. Eur Arch Psychiatry Clin Nuerosci 243, 244–248 (1994). https://doi.org/10.1007/BF02191582
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02191582