Skip to main content
SpringerLink
Log in

Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals

  • Perspectives Part II. Viral, Parasitic And Microbial Proteases
  • Published:
Perspectives in Drug Discovery and Design

Summary

Herpes group viruses encode a serine proteinase that is essential for the production of infectious virus. This chapter summarizes our current understanding of its biochemical and enzymatic properties, and considers its potential as a target for antivirals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Roizman, B., In Fields, B.N. and Knipe, D.M. (Eds.) Virology, Vol. 2, Raven Press, New York, NY, 1990, pp. 1787–1793.

    Google Scholar 

  2. Alford, C.A. and Britt, W.J., In Fields, B.N. and Knipe, D.M. (Eds.) Virology, Vol. 2, Raven Press, New York, NY, 1990, pp. 1981–2010.

    Google Scholar 

  3. Whitley, R.J., In Fields, B.N. and Knipe, D.M. (Eds.) Virology, Vol. 2, Raven Press, New York, NY, 1990, pp. 1843–1888.

    Google Scholar 

  4. Miller, G., In Fields, B.N. and Knipe, D.M. (Eds.) Virology, Vol. 2, Raven Press, New York, NY, 1990, pp. 1921–1958.

    Google Scholar 

  5. Gao, M., Matusick-Kuman, L., Hurlburt, W., DiTusa, S.F., Newcomb, W.W., Brown, J.C., McCann, P.J., Deckman, I. and Colonno, R.J., J. Virol., 68 (1994) 3702.

    Google Scholar 

  6. Preston, V.G., Coates, J.A. and Rixon, F.J., J. Virol., 45 (1983) 1056.

    Google Scholar 

  7. Barrett, A.J., Methods Enzymol., 244 (1994) 1.

    Google Scholar 

  8. Welch, A.R., Woods, A.S., McNally, L.M., Cotter, R.J. and Gibson, W., Proc. Natl. Acad. Sci. USA, 88 (1991) 10792.

    Google Scholar 

  9. Welch, A.R., McNally, L.M. and Gibson, W., J. Virol., 65 (1991) 4091.

    Google Scholar 

  10. Liu, F. and Roizman, B., J. Virol., 65 (1990) 206.

    Google Scholar 

  11. Liu, F. and Roizman, B., J. Virol., 65 (1991) 5149.

    Google Scholar 

  12. Welch, A.R., Woods, A.S., McNally, L.M., Cotter, R.J. and Gibson, W., Proc. Natl. Acad. Sci. USA, 88 (1991) 10792.

    Google Scholar 

  13. Welch, A.R., McNally, L.M., Hall, M.R.T. and Gibson, W., J. Virol., 67 (1993) 7360.

    Google Scholar 

  14. Burck, P.J., Berg, D.H., Luk, T.P., Sassmannshausen, L.M., Wakulchik, M., Becker, G.W., Smith, D.P., Hsiung, H.M., Gibson, W. and Villarreal, E.C., J. Virol., 68 (1994) 2937.

    Google Scholar 

  15. Baum, E.Z., Bebernitz, G.A., Hulmes, J.D., Muzithras, V.P., Jones, T.R. and Gluzman, Y., J. Virol., 67 (1993) 497.

    Google Scholar 

  16. Holwerda, B.C., Wittwer, A.J., Duffin, K.L., Smith, C., Toth, M.V., Carr, L.S., Wiegand, R.C. and Bryant, M.L., J. Biol. Chem., 269 (1994) 25911.

    Google Scholar 

  17. Sardana, V.V., Wolfgang, J.A., Veloski, C.A., Long, W.J., LeGrow, K., Wolanski, B., Emini, E.A. and LaFemina, R.L., J. Biol. Chem., 269 (1994) 14337.

    Google Scholar 

  18. Deckman, I.C., Hagen, M. and McCann III, P.J., J. Virol., 66 (1992) 7362.

    Google Scholar 

  19. Smith, M.C., Giordano, J., Cook, J.A., Wakulchik, M., Villarreal, E.C., Becker, G.W., Bemis, K., Labus, J. and Manetta, J.S., Methods Enzymol., 244 (1994) 412.

    Google Scholar 

  20. Darke, P.L., Chen, E., Hall, D.L., Sardana, M.K., Veloski, C.A., LeFemina, R.L., Shafer, J.A. and Kuo, L.C., J. Biol. Chem., 269 (1994) 18707.

    Google Scholar 

  21. Stevens, J.T., Mapelli, C., Tsao, J., Hail, M., O'Boyle, D., Weinheimer, S.P. and DiIanni, C.L., Eur. J. Biochem., 226 (1994) 361.

    Google Scholar 

  22. Thomsen, D.R., Roff, L.L. and Homa, F.L., J. Virol., 68 (1994) 2442.

    Google Scholar 

  23. Preston, V.G., Rixon, F.J., McDougall, I.M., McGregor, M. and Al Kobaisi, M.F., Virology, 186 (1992) 87.

    Google Scholar 

  24. Jones, T.R., Sun, L., Bebernitz, G.A., Muzithras, V.P., Kim, H.-J., Johnston, S.H. and Baum, E.Z., J. Virol., 68 (1994) 3742.

    Google Scholar 

  25. Tatman, J.D., Preston, V.G., Nicholson, P., Elliott, R.M. and Rixon, F.J., J. Gen. Virol., 75 (1994) 1101.

    Google Scholar 

  26. DiIanni, C.L., Mapelli, C., Drier, D.A., Tsao, J., Natarajan, S., Riexinger, D., Festin, S.M., Bolgar, M., Yamanaka, G., Weinheimer, S.P., Meyers, C.A., Colonno, R.J. and Cordingley, M.G., J. Biol. Chem., 268 (1993) 25449.

    Google Scholar 

  27. Liu, F. and Roizman, B., J. Virol., 67 (1993) 1300.

    Google Scholar 

  28. O'Boyle, D.R., Wager-Smith, K., Stevens, J.T. and Weinheimer, S.P., J. Biol. Chem., 270 (1995) 4753.

    Google Scholar 

  29. Hall, M.R.T. and Gibson, W., J. Virol., (1995) manuscript submitted for publication.

  30. Liu, F. and Roizman, B., Proc. Natl. Acad. Sci. USA, 89 (1992) 2076.

    Google Scholar 

  31. DiIanni, C.L., Stevens, J.T., Bolgar, M., O'Boyle, D.R., Weinheimer, S.P. and Colonno, R.J., J. Biol. Chem., 269 (1994) 12672.

    Google Scholar 

  32. Cox, G.A., Wakulchik, M., Sassmannshausen, L.M., Gibson, W. and Villarreal, E.C., J. Virol., 69 (1995) 4524.

    Google Scholar 

  33. Gorbalenya, A.E., Donchenko, A.P., Blinov, V.M. and Koonin, E.V., FEBS Lett., 243 (1989) 103.

    Google Scholar 

  34. Schrag, J.D., Li, Y., Wu, S. and Cygler, M., Nature, 351 (1991) 761.

    PubMed  Google Scholar 

  35. Barr, P.J., Cell, 66 (1991) 1.

    Google Scholar 

  36. Bazan, J.F. and Fletterick, R.J., Proc. Natl. Acad. Sci. USA, 85 (1988) 7872.

    Google Scholar 

  37. Gorbalenya, A.E., Koonin, E.V., Donchenko, A.P. and Blinov, V.M., Nucleic Acids Res., 17 (1989) 4847.

    Google Scholar 

  38. Schechter, I. and Berger, A., Biochem. Biophys. Res. Commun., 27 (1967) 157.

    Google Scholar 

  39. McCann, P.J., O'Boyle, D.R. and Deckman, I.C., J. Virol., 68 (1994) 526.

    Google Scholar 

  40. Gibson, W., Welch, A.R. and Ludford, J., Methods Enzymol., 244 (1994) 399.

    Google Scholar 

  41. Loutsch, J.M., Galvin, N.J., Bryant, M.L. and Holwerda, B.C., Biochem. Biophys. Res. Commun., 203 (1994) 472.

    Google Scholar 

  42. Welch, A.R., Villarreal, E.C. and Gibson, W., J. Virol., 69 (1995) 341.

    Google Scholar 

  43. Jupp, R. and Donaghy, G., J. Virol., 69 (1995) 1265.

    Google Scholar 

  44. Meek, T.D., Dayton, B.D., Metcalf, B.W., Dreyer, G.B., Strickler, J.El., Gorniak, J.G., Rosenberg, M., Moore, M.L., Magaard, V.W. and Debouck, C., Proc. Natl. Acad. Sci. USA, 86 (1989) 1841.

    Google Scholar 

  45. Cordingly, M.G., Register, R.B., Callahan, P.L., Garsky, V.M. and Colonno, R.J., J. Virol., 63 (1989) 5037.

    Google Scholar 

  46. Rixon, F.J., Semin. Virol., 4 (1993) 135.

    Google Scholar 

  47. Gibson, W., Molecular Aspects of Human Cytomegalovirus Diseases, Springer, New York, NY, 1993, pp. 303–329.

    Google Scholar 

  48. Thomsen, D.R., Newcomb, W.W., Brown, J.C. and Homa, F.L., J. Virol., 69 (1995) 3690.

    Google Scholar 

  49. Matusick-Kumar, L., Newcomb, W.W., Brown, J.C., McCann, P.C., Hurlburt, W., Weinheimer, S.P. and Gao, M., J. Virol., (1995) in press.

  50. Wood, L.J., Baxter, M.J. and Gibson, W., J. Virol., manuscript submitted for publication.

  51. Nicholson, P., Addison, C., Cross, A.M., Kennard, J., Preston, V.G. and Rixon, F.J., J. Gen. Virol., 75 (1994) 1091.

    Google Scholar 

  52. Gibson, W., Virology, 111 (1981) 516.

    Google Scholar 

  53. Newcomb, W.W., Trus, B.L., Booy, F.P., Steven, A.C., Wall, J.S. and Brown, J.C., J. Mol. Biol., 232 (1993) 499.

    Google Scholar 

  54. Schenk, P., Woods, A.S. and Gibson, W., J. Virol., 65 (1991) 1525.

    Google Scholar 

  55. Roizman, R.B., Carmichael, L.E., Deinhardt, F., de The, G., Nahmias, A.J., Plowright, W., Rapp, F., Sheldrick, P., Takahashi, M. and Wolf, K., Intervirology, 16 (1981) 201.

    Google Scholar 

  56. Long, E.O., Rosen-Bronson, S., Karp, D.R., Malnati, M., Sekaly, R.P. and Jaraquemada, D., Hum. Immunol., 31 (1991) 229.

    Google Scholar 

Download references

Author information

Author notes

  1. Anthony R. Welch

    Present address: Syntex Discovery Research, Institute of Biochemistry and Cell Biology, 94304, Palo Alto, CA, U.S.A.

Authors and Affiliations

  1. Virology Laboratories, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University, School of Medicine, 725 North Wolfe Street, 21205, Baltimore, MD, U.S.A.

    Wade Gibson, Anthony R. Welch & Matthew R. T. Hall

Authors
  1. Wade Gibson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anthony R. Welch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Matthew R. T. Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gibson, W., Welch, A.R. & Hall, M.R.T. Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals. Perspectives in Drug Discovery and Design 2, 413–426 (1995). https://doi.org/10.1007/BF02172034

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02172034

Key words

Search

Navigation