Abstract
Staining of lymphocytes from scrapie-infected STU mice with FITC-labelled anti-mouse Ig revealed disturbances in the capping process when compared with lymphocytes from mock-infected animals. Quantitative evaluation indicates that 10–15% of cells from scrapie-infected animals show an altered capping behaviour.
These phenomena are discussed with special reference to the role of the lymphoreticular system in early scrapie agent replication.
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References
Gardiner AC, Marucci AA (1969) Immunological responsiveness of scrapie infected mice. J Comp Path 79:233–235
Kimberlin RH (1976) Experimental scrapie in the mouse: a review of an important model disease. Sci Progr Oxf 63:461–481
Porter DD, Porter HG, Cox NA (1973) Failure to demonstrate a humoral immunresponse to scrapie infection in mice. J Immunol 3:1407–1410
Raff MC, Sternberg M, Taylor RB (1970) Immunglobulin determinants on the surface of mouse lymphoid cells. Nature 225: 553–554
Schäfer W (1979) Der Mäuse-Inzuchtstamm STU. Entwicklung und Eigenschaften. Z Naturforsch 34c:306–309
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Vettermann, W., Werner, H.J., Schmeißer, S. et al. Observation on the capping of spleen lymphocytes from scrapie infected mice after treatment with anti Ig. Med Microbiol Immunol 169, 75–81 (1981). https://doi.org/10.1007/BF02171774
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DOI: https://doi.org/10.1007/BF02171774