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Intraocular non-Hodgkin's lymphoma treated with systemic and intrathecal chemotherapy and radiotherapy

A case report and review of the literature

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Abstract

A case of therapy-resistant bilateral intermediate uveitis is presented. Vitreous biopsy and lumbar puncture resulted in the diagnosis of high-grade malignant non-Hodgkin's lymphoma (NHL). Because chemotherapy and radiotherapy continue to yield better results in the treatment of NHL and a cure can be reached in a large group of patients with high-grade malignant NHL, early diagnosis is very important. We therefore recommend early vitreous biopsy in persistent, bilateral, granulomatous intermediate uveitis, especially in older patients. Our patient achieved a complete remission (follow-up period at the time of writing, 18 months after the beginning of polychemotherapy and radiotherapy). The chemotherapy modalities are briefly discussed.

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Authors and Affiliations

  1. Department of Ophthalmology, Free University Hospital, P.O. Box 7057, 7007 MB, Amsterdam, The Netherlands

    A. J. P. Rouwen & T. N. Boen-Tan

  2. Department of Hematology, Free University Hospital, Amsterdam, The Netherlands

    P. W. Wijermans

  3. Department of Ophthalmology, State University, Utrecht, The Netherlands

    J. S. Stilma

Authors
  1. A. J. P. Rouwen
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  2. P. W. Wijermans
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  3. T. N. Boen-Tan
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  4. J. S. Stilma
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Rouwen, A.J.P., Wijermans, P.W., Boen-Tan, T.N. et al. Intraocular non-Hodgkin's lymphoma treated with systemic and intrathecal chemotherapy and radiotherapy. Graefe's Arch Clin Exp Ophthalmol 227, 355–359 (1989). https://doi.org/10.1007/BF02169412

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  • DOI: https://doi.org/10.1007/BF02169412

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