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Activité gonadotrope d'un extrait d'urines de femmes en ménopause

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Summary

In agreement with earlier observations on hypophysectomized male rats, a purified extract from pooled menopausal urine has been shown to contain follicle-stimulating (FSH) as well as luteinizing (LH) activity. Its administration to immature hypophysectomized female rats increased ovarian and uterine weights and induced follicle growth and the formation of corpora lutea. If the activity of the extract is measured in standardized units by bioassay in intact female mice using the uterine weight, the dose needed for corpus luteum formation in the hypophysectomized female rat seems to be approximately ten times higher than the dose producing interstitial cell repair and complete spermatogenesis in the hypophysectomized male.

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References

  1. R. Borth, B. Lunenfeld etH. de Watteville, Exper.10, 266 (1954).

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  2. Selon un accord de plusieurs laboratoires européens (2nd Meeting of the Gonadotrophin Club, Birmingham, 17 au 19 août 1955), une unité de gonadostimulines hypophysaires urinaires humaines a été définie provisoirement comme égale à l'activité gonadotrope contenue dans 1,0 mg de la préparation HMG-20A qui a été préparée par la Maison Organon à Newhouse en Ecosse, à partir d'une grande quantité d'urine provenant de très nombreuses femmes en ménopause (Human MenopausalGonadotrophin). Cette préparation sert actuellement comme standard de référence pour le dosage des gonadotrophines urinaires humaines en dehors de la grossesse. Cf.J.A. Loraine etJ. B. Brown, J. clin. Endocrin.16, 1180 (1956).

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  4. Nous remercions vivement le Dr S. G. Johnsen (Copenhague) qui a bien voulu mettre à notre disposition des échantillons de cet extrait.

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Authors and Affiliations

  1. Laboratoire d'Hormonologie de la Maternité, Genève

    R. Borth, B. Lunenfeld, G. Riotton & H. de Watteville

Authors
  1. R. Borth
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  2. B. Lunenfeld
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  3. G. Riotton
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  4. H. de Watteville
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Additional information

2e Communication: Effets sur les ovaires de rates impubères hypophysectomisées.

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Borth, R., Lunenfeld, B., Riotton, G. et al. Activité gonadotrope d'un extrait d'urines de femmes en ménopause. Experientia 13, 115–117 (1957). https://doi.org/10.1007/BF02157567

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  • DOI: https://doi.org/10.1007/BF02157567

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