Summary
In the experimental B1-avitaminosis a decrease of oxidative ATP-resynthesis in liver homogenates, and a significant diminution of the optical density of mitochondrial suspension were simultaneously observed: in other words a probable parallelism in the alteration of function and structure. In ariboflavinosis neither oxidative phosphorylation nor optical density seems to be notably impaired, but the nitrogen content of mitochondrial suspensions decreases significantly. Therefore this second type of avitaminosis would appear to affect the mitochondrial population rather than energetic metabolism or structural integrity of the protoplasmic granules.
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Communication présentée au 3e Congrès International de Biochimie, Bruxelles 1955.
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Frei, J., Ryser, H. Relations entre oxydation phosphorylante et structure des mitochondries hépatiques de rats carencés en vitamines B1 et B2. Experientia 12, 105–107 (1956). https://doi.org/10.1007/BF02157178
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DOI: https://doi.org/10.1007/BF02157178