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Influence of a mixture of radioprotectors on the mucosa of the small intestine of mice irradiated with 2000 R of X-rays

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  • Chimica. Biochimica. Biophysica
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Abstract

Our results on the number of nuclei, pycnoses, karyorrhexis and mitoses in protected irradiated mice demonstrate that mixtures of chemical protectors largely diminish the lesions produced in the stem cells of the duodenum of mice irradiated with 2000 R of X-rays, but a delay of about 30 days is nevertheless needed to allow complete recovery of the duodenal mucosa.

Résumé

Nos résultats sur le nombre de noyaux, de pycnoses, de caryorrexis et de mitoses, chez les souris protégées et irradiées, montrent que des associations de substances radioprotectrices diminuent fortement les lésions produites dans les cellules souches du duodénum de souris irradiées avec une dose de 2000 R de rayons X; un délai d'au moins 30 jours est néanmoins nécessaire avant que la muqueuse duodénale ait retrouvé un aspect entièrement normal.

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Literatur

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This work was supported in part by research contract A.I.E.A. No. 347/RB and by grants from the ‘Fonds de la Recherche scientifique fondamentale collective’.

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Maisin, J.R., Lambiet-Collier, M. Influence of a mixture of radioprotectors on the mucosa of the small intestine of mice irradiated with 2000 R of X-rays. Experientia 24, 338–339 (1968). https://doi.org/10.1007/BF02140807

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  • DOI: https://doi.org/10.1007/BF02140807

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