Summary
Animal experiments and clinical observations have raised the question of liver function in patients on long-term, high-dose administration of sex steroids. The effective treatment of androgenisation demands the prolonged administration of the antiandrogen cyproterone acetate (CPA), which is also a highly effective progestogen. Biochemical tests of liver function and ultrasonographic examinations were performed in 77 women who had been treated with CPA given in the reverse sequential scheme — 100 mg CPA/day from the 1st–10th day combined with 2 mg CPA + 0.05 mg ethinylestradiol/day from the 1st-21st day of each treatment cycle — for 3 to 11 years. No disturbances of the liver structure or function were found.
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Kaiser, E., Gruner, H.S. Liver structure and function during long-term treatment with cyproterone acetate. Arch. Gynecol. 240, 217–223 (1987). https://doi.org/10.1007/BF02134071
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DOI: https://doi.org/10.1007/BF02134071