Abstract
Urinary prostaglandin E(PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was urinary osmolality (Uosm) and the ratio urine to plasma osmolality (Uosm/Posm); and a negative correlation between urinary cAMP excretion and urine volume. A negative correlation was observed between the values of PGE excretion and urinary cAMP. These data confirmed the role of PGE as a modulator of cAMP production, which was inhibited in the nephrotic syndrome.
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Túri, S., Havass, Z. & Bodrogi, T. The role of renal prostaglandin E as a possible modulator of cyclic AMP production in nephrotic syndrome. International Urology and Nephrology 18, 321–325 (1986). https://doi.org/10.1007/BF02082721
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DOI: https://doi.org/10.1007/BF02082721