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Potassium-induced histamine release from mast cells and its inhibition by ketotifen

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Abstract

Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 mM in the absence of extracellular Ca2+. Potassium concentrations greater than 150 mM produced less histamine release. The release was energy-dependent and was complete within one minute. The histamine liberating effect of KCl could be inhibited by NaCl and by preincubation with ketotifen. The monovalent cations, Rb+ and Cs+ also evoked histamine release, whereas Na+ and Li+ were ineffective.

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References

  1. P. Magyar, M. Dervaderics and A. Tóth,Bronchial challenge with hypertonic KCl solution in the diagnosis of bronchial asthma. Schweiz. med. Wschr.114, 910–914 (1984).

    PubMed  Google Scholar 

  2. D. E. Cochrane and W. W. Douglas,Histamine release by exocytosis from rat mast cells on reduction of extracellular sodium: a secretory response inhibited by calcium, strontium, barium or magnesium. J. Physiol.257, 433–448 (1976).

    PubMed  Google Scholar 

  3. N. Frossard, M. Amellal and Y. Landry,Sodium-potassium ATPase, calcium and immunological histamine release. Biochem. Pharmac.32, 3259–3262 (1983).

    Google Scholar 

  4. A. Németh and P. Röhlich,Rapid separation of peritoneal mast cells with Percoll. Eur. J. Cell Biol.20, 272–275 (1980).

    PubMed  Google Scholar 

  5. P. A. Shore, A. Burkhalter and V. H. Cohn,A method for fluorometric assay of histamine in tissues. J. Pharmac. exp. Ther.127, 182–186 (1959).

    Google Scholar 

  6. F. L. Pearce and J. R. White,Calcium efflux and histamine secretion from rat peritoneal mast cells. Agents and Actions14, 392–396 (1984).

    PubMed  Google Scholar 

  7. B. T. Kanner and H. Metzger,Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. Proc. Natl. Acad. Sci. USA80, 5744–5748 (1983).

    PubMed  Google Scholar 

  8. R. Sagi-Eisenberg and I. Pecht,Membrane potential changes during IgE-mediated histamine release from rat basophilic leukemia cells. J. Membr. Biol.75, 97–104 (1983).

    PubMed  Google Scholar 

  9. M. Ennis, A. Truneh, J. R. White and F. L. Pearce,Inhibition of histamine secretion from mast cells. Nature289, 186–187 (1981).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratory I of Electron Microscopy, Semmelweis University of Medicine, Tüzoltó u. 58, H-1450, Budapest, Hungary

    A. Németh

  2. Department of Pulmonology, Semmelweis University of Medicine, Tüzoltó u. 58, H-1450, Budapest, Hungary

    P. Magyar & R. Herceg

  3. Department of Pharmacodynamics, Semmelweis University of Medicine, Tüzoltó u. 58, H-1450, Budapest, Hungary

    Z. Huszti

Authors
  1. A. Németh
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  2. P. Magyar
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  3. R. Herceg
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  4. Z. Huszti
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Németh, A., Magyar, P., Herceg, R. et al. Potassium-induced histamine release from mast cells and its inhibition by ketotifen. Agents and Actions 20, 149–152 (1987). https://doi.org/10.1007/BF02074654

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