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Radiosensitization of thymine by Fe(III)-1,2 dihydroxyanthraquinone complex in dilute aqueous solution

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Abstract

A complex of Fe(III) with 1,2 dihydroxy 9, 10, anthraquinone (DHA) has been prepared. The metal ion forms a 1∶3 complex with DHA. The complex is formed due to the dissociation of one proton per ligand bound to the metal ion. The stability constant of the Fe(III) complex is 1.61·1032. The complex reduces the catalytic flow of electrons from NADH to molecular O2 through NADH dehydrogenase over DHA. The Fe(III) compelx is seen to be an efficient radiosensitizer towards γ-radiation induced degradation of thymine in a nitrous oxide saturated medium.

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  1. Nuclear Chemistry Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, 700 064, Calcutta, India

    Saurabh Das, A. Saha & P. C. Mandal

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  1. Saurabh Das
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  2. A. Saha
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  3. P. C. Mandal
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Das, S., Saha, A. & Mandal, P.C. Radiosensitization of thymine by Fe(III)-1,2 dihydroxyanthraquinone complex in dilute aqueous solution. Journal of Radioanalytical and Nuclear Chemistry, Articles 196, 57–63 (1995). https://doi.org/10.1007/BF02036289

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