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Hypothalamic-pituitary-adrenal (HPA) axis function in patients receiving long-term intra-articular corticosteroids

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Summary

The hypothalamic-pituitary-adrenal (HPA) axis function of eight patients with rheumatoid arthritis receiving regular intra-articular methyl prednisolone acetate was studied. Tests of the HPA axis 5–7 weeks after the last injection revealed suppression in two patients. Some patients receiving intra-articular corticosteroids may therefore have abnormal responses to stress.

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References

  1. Chandler, G.N., Wright, V. Deleterious effects of intra-articular hydrocortisone. Lancet 1958, 2, 661–663.

    PubMed  Google Scholar 

  2. Chandler, G.N., Jones, D.T., Wright, V., Hertfall, S.J. Charcots' artropathy following intra-articular hydrocortisone. Br med J 1959, 1, 952–953.

    Google Scholar 

  3. Steinberg, C., Duthie, R.B., Priva, A.E. Charcotlike arthropathy following intra-articular hydrocortisone injections. JAMA 1962, 181, 851–854.

    PubMed  Google Scholar 

  4. Bentley, G., Goodfellow, J.W. Disorganisation of the knees following intra-articular hydrocortisone injections. J. Bone Joint Surg 1969, 51B, 498–502.

    Google Scholar 

  5. Balch, H.W., Gibson, J.M.C., El-Ghobarey, A.F., Bain, L.S., Lynch, M.P. Repeated corticosteroid injections into knee joints. Rheumatol Rehabil 1977, 16, 137–140.

    PubMed  Google Scholar 

  6. Shushter, S., Williams, I.A. Adrenal suppression due to intra-articular corticosteroid therapy. Lancet 1961, 2, 171–172.

    Google Scholar 

  7. Bain, L.S., Jacomb, R.G., Wynn, V. Parenteral administration of 6 methyl prednisolone-21-acetate. Part II-absorption and duration of effect. Ann Phys Med 1967, 9, 49–54.

    PubMed  Google Scholar 

  8. Koehler, B.E., Urowitz, M.B., Killinger, D.W. The systemic effect of intra-articular corticosteroids. J. Rheumatol 1974, 1, 117–125.

    PubMed  Google Scholar 

  9. Bird, H.A., Ring, E.F.J., Bacon, P.A. A thermographic and clinical comparison of three intra-articular steroid preparations in rheumatoid arthritis. Ann Rheum Dis 1979, 38, 36–39.

    PubMed  Google Scholar 

  10. Armstrong, R.D., English, J., Gibson, J., Chakrabarty, J., Marks, V. Serum methyl prednisolone levels following intra-articular injection of methyl prednisolone acetate. Ann Rheum Dis 1981, 40, 571–574.

    PubMed  Google Scholar 

  11. Ropes, M., Bennett, J., Cobb, S., Jacox, R., Jessar, R.A. Revision of diagnostic criteria for rheumatoid arthritis. Arthritis Rheum 1958, 2, 16–20.

    Google Scholar 

  12. Mattingly, D. A simple flurometric method for the estimation of free 11; hydroxycorticosteroids in human plasma. J Clin Pathol 1962, 15, 374–379.

    PubMed  Google Scholar 

  13. James, V.H.T., Landon, J. Hypothalamic-pituitary-adrenal function tests. Published by CIBA Laboratories 1976, 72.

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Reid, D.M., Patel, S., Reid, I.W. et al. Hypothalamic-pituitary-adrenal (HPA) axis function in patients receiving long-term intra-articular corticosteroids. Clin Rheumatol 2, 159–161 (1983). https://doi.org/10.1007/BF02032173

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  • DOI: https://doi.org/10.1007/BF02032173

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