Abstract
It was found that in vitro, histidine and histamine form a complex compound with pyridoxal-5′-phosphate (PLP). The purpose of the present experiments was to find whether formation of this complex can influence histidine decarboxylase activity.
It was found that excess PLP inhibits rat's gastric mucosa histidine decarboxylase activity in vitro. The inhibitory action of PLP depends on the histidine concentration and is independent on the amount of crude enzyme preparation. The histidine-PLP complex did not influence enzyme activity. The possible mechanisms of the inhibitory action of PLP on histidine decarboxylase activity are discussed.
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References
D. Kierska andCz. Maśliński,Condition for the Formation of Cyclic Compound between Pyridoxal Phosphate and some Imidazole Derivatives, Biochem. Pharmac.20, 1951–1959 (1971).
Cz. Maśliński andD. Kierska,Selected, Problems of Regulation of the Biogenic Amines in the Body, Ann. Med. Sect. Pol. Acad. Sci.19, 167–183 (1972).
J.B. Black andJ. Axelrod,Inhibition of Tyrosine Transaminase Activity by Norepinephrine, J. Biol. Chem.244, 6124–6129 (1969).
H.F. Schott andW.G. Clark,Dopa-decarboxylase Inhibition through the Interaction of Coenzyme and Substrate, J. Biol. Chem.196, 449–461 (1952).
H. Mesch andK.Fr. Sewing,The Effect of Brocresine on the Histidine Decarboxylase Activity in the Rat Gastric Mucosa, J. Pharm. Pharmac.196, 506–508 (1971).
P.A. Shore, A. Burhalter andV.H. Cohn,A Method of the Fluorometric Assay of Histamine in Tissues, J. Pharmac. exp. Ther.127, 182–186 (1959).
H. Wada andE.E. Snell,The Enzymatic Oxidation of Pyridoxine and Pyridoxyamine Phosphates, J. Biol. Chem.236, 2089–2095 (1961).
H. Lineweaver andD. Burk,The Determination of Enzyme Dissociation Constant, J. Am. Chem. Soc.56, 658–666 (1934).
O. Avramovic-Zikic andN.B. Madsen,Paradoxical Inhibition of Phosphorylase b by Pyridoxal-5′-phosphate, J. Biol. Chem.247, 6999–7004 (1972).
R.W. Trewyn, K.D. Nakamura, M.L. O'Connor andL.W. Parks,An Interaction between S-adenosyl-L-methinine and Pyridoxal-5′-phosphate and its Effect on Saccharomyces Cerevisiae, Biochem. Biophys. Acta327, 336–343 (1973).
A. Pestana, J.V. Sandoval andA. Sols,Inhibition by Homocysteine of Serine Dehydratese and Other Pyridoxal-5′-phosphates Enzymes of the Rat through Cofactor Blockage, Arch. Biochem. Biophys.146, 373–379 (1971).
J.T. Neary, R.L. Menecly, M.R. Grever andW.F. Diven,The Interaction between Biogenic Amines and Pyridoxal, Pyridoxal-5′-phosphate and Pyridoxal Kinase, Arch. Biochem. Biophys.151, 42–47 (1972).
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Wohl, K., Maśliński, C. Phosphopyridoxal complexes with histamine and histidine (2) the influence of presumed complex on histidine decarboxylase activity in rat gastric mucosa. Agents and Actions 5, 20–24 (1975). https://doi.org/10.1007/BF02027153
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DOI: https://doi.org/10.1007/BF02027153