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Regulation of macrophage phagocytosis

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Abstract

The removal of pathogens from the circulation is achieved primarily by cells of the mononuclear phagocyte system, also known as the reticuloendothelial system. The tissue macrophage is the most important component of this system. The phagocytic activity of macrophages is regulated by opsonins on pathogenic materials and by endogenous cytokines. A number of diseases are caused by qualitative or quantitative disorders of phagocytosis by four major mechanisms: a decrease in the flow of blood to organs which contain macrophages (e.g. congestive heart failure and portal hypertension); a decrease in the quantity of tissue which contains macrophages (e.g. hepatic cirrhosis and splenectomy); a decrease in the effective opsonization of pathogens because of a deficiency of complement or IgG; and qualitative dysfunction of macrophages due to a deficiency of regulatory cytokines (e.g. gamma interferon and tuftsin) or a direct inhibitory effect on the macrophage (e.g. viral infections). New approaches for selective regulation of the phagocytic activity of macrophages are emerging.

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References

  1. Brouwer, A., Knook, D. L.: The reticuloendothelial system and aging. A review. Mechanisms of Aging and Development 1983, 21: 205–228.

    Google Scholar 

  2. Frank, M. M., Lawley, T. J., Hamburger, M. I., Brown, E. J.: Immunoglobulin G Fc receptor-mediated clearance in autoimmune diseases. Annals of Internal Medicine 1983, 98: 206–218.

    PubMed  Google Scholar 

  3. Stossel, T. P.: Phagocytosis. New England Journal of Medicine 1974, 290: 717–723, 774–780, 833–839.

    PubMed  Google Scholar 

  4. Silverstein, S. C., Steinman, R. M., Cohn, Z. A.: Endocytosis. Annual Review of Biochemistry 1977, 46: 669–722.

    PubMed  Google Scholar 

  5. Johnson, W. D., Mei, B., Cohn, Z. A.: The separation, long-term cultivation and maturation of the human monocyte. Journal of Experimental Medicine 1977, 146: 1613–1626.

    PubMed  Google Scholar 

  6. Montesano, R., Mossaz, A., Vasalli, P., Orci, L.: Specialization of the macrophage plasma membrane at sites of interaction with opsonized erythrocytes. Journal of Cell Biology 1983, 96: 1227–1233.

    PubMed  Google Scholar 

  7. Mellman, I. S., Plutner, H., Steinman, R. M., Unkeless, J. C., Cohn, Z. A.: Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis. Journal of Cell Biology 1983, 96: 887–895.

    PubMed  Google Scholar 

  8. Fearon, D. T.: Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte and monocyte. Journal of Experimental Medicine 1980, 152: 20–30.

    PubMed  Google Scholar 

  9. Moulder, J. W.: Comparative biology of intracellular parasitism. Microbiological Reviews 1985, 49: 298–337.

    PubMed  Google Scholar 

  10. Yoshie, O., Mellman, I. S., Broeze, R. J., Garcia-Blanco, M., Lengyel, P.: Interferon action: effects of mouse alpha and beta interferons on rosette formation, phagocytosis and surface antigen expression of cells of the macrophage-type line RAW 309 Cr 1. Cellular Immunology 1982, 73: 128–140.

    PubMed  Google Scholar 

  11. Coleman, D. L., Culver, K. E., Ryan, J. L.: Effect of lipopolysaccharide on the stimulation of macrophage Fc-dependent phagocytosis by splenic B lymphocytes. Cellular Immunology 1985, 91: 520–527.

    PubMed  Google Scholar 

  12. Griffin, F. M., Luben, R. A., Golde, D. W.: A human lymphokine activates macrophage C3 receptors for phagocytosis. Studies using monoclonal anti-lymphokine antibodies. Journal of Leukocyte Biology 1984, 36: 95–109.

    PubMed  Google Scholar 

  13. Coleman, D. L., Culver, K. E., Ryan, J. L.: Enhancement of immune and nonimmune receptor-mediated phagocytosis by a low molecular weight soluble factor from resident thymocytes. Journal of Immunology 1984, 133: 3121–3127.

    Google Scholar 

  14. Foris, G., Fust, G., Medgyesi, G. A.: The effect of oligopeptides on the C3b receptor-mediated functions of rat Macrophages. Immunology Letters 1983, 6: 7–11.

    PubMed  Google Scholar 

  15. Ghezzo, F., Garbarino, G., Ioverno, L.: Insulin modulates human mononuclear adherent cell fibrinolytic and phagocytic activities. Scandinavian Journal of Hematology 1983, 30: 379–383.

    Google Scholar 

  16. Dodd, R. C., Cohen, M. S., Newman, S. L., Gray, T. K.: Vitamin D metabolites change the phenotype of monoblastic U 937 cells. Proceedings of the National Academy of Sciences 1983, 80: 7538–7541.

    Google Scholar 

  17. Czop, J. K., Austen, F.: Augmentation of phagocytosis by a specific fibronectin fragment that links particulate activators to the fibronectin adherence receptor on human monocytes. Journal of Immunology 1982, 129: 2678–2681.

    Google Scholar 

  18. Pearson, H. A., Cornelius, E. A., Schwartz, A. D., Zelson, J. H., Wolfson, S. L., Spencer, R. P.: Transfusionreversible functional asplenia in young children with sickle-cell anemia. New England Journal of Medicine 1970, 283: 334–337.

    PubMed  Google Scholar 

  19. Rimola, A., Soto, R., Bory, F., Arroyo, V., Piera, C., Rodes, J.: Reticuloendothelial system. Phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis. Hepatology 1984, 4: 53–58.

    PubMed  Google Scholar 

  20. Hosea, S. W., Brown, E. J., Hamburger, M. I., Frank, M. M.: Opsonic requirements for intravascular clearance after splenectomy. New England Journal of Medicine 1981, 304: 245–250.

    PubMed  Google Scholar 

  21. Jaffe, C. J., Vierling, J. M., Jones, E. A., Lawley, T. J., Frank, M. M.: Receptor specific clearance by the reticuloendothelial system in chronic liver diseases: demonstration of defective C3b-specific clearance in primary biliary cirrhosis. Journal of Clinical Investigation 1978, 62: 1069–1077.

    PubMed  Google Scholar 

  22. McMillan, R.: Chronic idiopathic thrombocytopenic purpura. New England Journal of Medicine 1981, 304: 1135–1147.

    PubMed  Google Scholar 

  23. Root, R. K., Ryan, J. L.: Humoral immunity and complement. In: Mandell, G. L., Douglas, R. G., Bennett, J. E. (ed.): Principles and practice of infectious diseases. John Wiley, New York, NY, 1985, p. 31–57.

    Google Scholar 

  24. Miller, D. G.: Patterns of immunologic deficiency in lymphomas and leukemias. Annals of Internal Medicine 1962, 77: 703–716.

    Google Scholar 

  25. Bjornson, A. B., Altmeier, W. A., Bjornson, H. S.: Changes in humoral components of host defense following burn trauma. Annals of Surgery 1977, 186: 88–96.

    PubMed  Google Scholar 

  26. Waldmann, T. A., Strober, W.: Metabolism of immunoglobulins. Progress in Allergy 1969, 13: 1–110.

    PubMed  Google Scholar 

  27. Ross, S. C., Densen, P.: Complement deficiency states and infection: epidemiology, pathogenesis, and consequences of neisserial infections in an immune deficiency. Medicine 1984, 63: 243–273.

    PubMed  Google Scholar 

  28. Parris, T. M., Kimberly, R. P., Inman, R. D., McDougal, J. S., Gibofsky, A., Christian, C. L.: Defective Fc-receptor mediated function of the mononuclear phagocyte system in lupus nephritis. Annals of Internal Medicine 1982, 97: 526–532.

    PubMed  Google Scholar 

  29. Shapiro, E. D., Clemens, J. D.: A controlled evaluation of the protective efficacy of pneumococcal vaccine for patients at high risk of serious pneumococcal infection. Annals of Internal Medicine 1984, 101: 325–330.

    PubMed  Google Scholar 

  30. Advisory Committee on Immunization Practices: Meningococcal vaccines. Morbidity and Mortality Weekly Reports 1985, 34: 255–259.

    Google Scholar 

  31. Advisory Committee on Immunization Practices: Polysaccharide vaccine for prevention ofHaemophilus influenza type b disease. Morbidity and Morality Weekly Reports 1985, 34: 201–205.

    Google Scholar 

  32. Fehr, J., Hoffman, V., Kappeler, U.: Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high dose intravenous gamma globulin. New England Journal of Medicine 1982, 306: 1254–1258.

    PubMed  Google Scholar 

  33. Forsgren, A., Sjoguist, J.: “Protein A” fromStaphylococcus aureus, I: Pseudo-immune reaction with human globulin. Journal of Immunology 1966, 97: 822–827.

    Google Scholar 

  34. Bisno, A. L.:Streptococcus pyogenes. In: Mandell, G. L., Douglas, R. G., Bennett, J. E. (eds.): Principles and practice of infectious diseases. John Wiley, New York, NY, 1985, p. 1124–1132.

    Google Scholar 

  35. Plaeger-Marshall, S., Wilson, L. A., Smith, J. W.: Alteration of rabbit alveolar and pertoneal macrophage function by herpes simplex virus. Infection and Immunity 1983, 41: 1375–1379.

    Google Scholar 

  36. Schmit, K. E., Powell, D. A.: Phagocytic dysfunction in monocytes of normal newborn infants. Pediatrics 1977, 65: 501–504.

    Google Scholar 

  37. Hamm, M. W., Winick, M.: Effect of protein restriction on macrophage phagocytic capacity in young mice. Journal of Nutrition 1984, 114: 511–517.

    PubMed  Google Scholar 

  38. Kimberley, R. P., Gibofsky, A., Salmon, J. E., Fotino, M.: Impaired Fc-meditated mononuclear phagocyte system clearance in HLA-DR2 and MT-1 positive healthy young adults. Journal of Experimental Medicine 1983, 157: 1698–1703.

    PubMed  Google Scholar 

  39. Kuratsune, H., Koda, T., Kurahori, T.: The relationship between endotoxin and the phagocytic activity of the reticuloendothelial system. Hepato-gastroenterology 1983, 30: 79–82.

    PubMed  Google Scholar 

  40. Atkinson, J. P., Schreiber, A. S., Frank, M. M.: Effects of corticosteroid and splenectomy on the immune clearance and destruction of erythrocytes. Journal of Clinical Investigation 1973, 52: 1509–1517.

    PubMed  Google Scholar 

  41. Tubaro, E., Borelli, G., Croce, C., Cavallo, G., Santian-geli, C.: Effect of morphine on resistance to infection. Journal of Infectious Diseases 1983, 148: 656–666.

    PubMed  Google Scholar 

  42. Murray, H. W., Rubin, B. Y., Masur, H., Roberts, R. B.: Impaired production of lymphokines and immune (gamma) interferon in the acquired immune deficiency syndrome. New England Journal of Medicine 1984, 310: 883–889.

    PubMed  Google Scholar 

  43. Nishioka, K., Amoscato, A. A., Babcock, G. F., Banks, R. A., Phillips, J. H.: Tuftsin: an immunomodulating peptide hormone and its clinical potential as a natural biologic response modifier. Cancer Investigation 1984, 2: 39–49.

    PubMed  Google Scholar 

  44. Constantopoulos, A., Najjar, V. A.: Tuftsin deficiency syndrome. Acta Pediatrica Scandinavia 1973, 62: 645–648.

    Google Scholar 

  45. Koff, W. C., Fidler, I. J., Showalter, S. D., Chabrabarty, M. K., Hampar, B., Ceccorulli, L. M., Kleinerman, E. S.: Human monocytes activated by immunomodulators in liposomes lyse herpes virus-infected but not normal cells. Science 1984, 224: 1007–1009.

    PubMed  Google Scholar 

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  1. Medical Service (III), Veterans Administration Medical Center, 06516, West Haven, Connecticut, USA

    D. L. Coleman

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Coleman, D.L. Regulation of macrophage phagocytosis. Eur. J, Clin. Microbiol. 5, 1–5 (1986). https://doi.org/10.1007/BF02013451

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