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Radiocalcium studies in normal subjects

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Abstract

Twelve normal subjects have been studied using calcium balance techniques and47Ca to provide normal reference values for metabolic calcium studies in adult humans. A composite graph of plasma and urinary calcium specific activities is presented at intervals from 0.1 to 300 hours after isotope injection. It is suggested that an adequate representation of this data may be made by means of two power functions, and the practicality of this interpretation is discussed.

Résumé

Des techniques permettan l'étude de l'équilibre calcique et du47calcium ont été utilisées chez douze sujets normaux pour apprécier le métabolisme calcique chez l'homme adulte. Un graphique des activités spécifiques du calcium plasmatique et urinaire est dressé de 0.1 à 300 heures après l'injection isotopique. Il semble qu'une interprétation satisfaisante de ces résultats puisse étre réalisée à l'aide de deux fonctions de puissance et l'intérêt de cette interprétation est analysé.

Zusammenfassung

12 Gesunde wurden mit der Ca-Bilanztechnik unter Verwendung von Ca47 untersucht, um Bezugsgrößen für Ca-Stoffwechseluntersuchungen bei Erwachsenen zu erhalten. Ein Diagramm der spezifischen Aktivitäten im Plasma und Harn 0,1–300 Std nach einer Isotopeninjektion wird dargestellt. Man folgert, daß eine gleichmäßige Wicdergabe dieser Werte durch eine zweigliedrige Funktion möglich ist; die praktische Bedeutung dieser Interpretation wird diskutiert.

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References

  • Anderson, J., E. W. Emery, J. M. McAllister, andS. B. Osborn: The metabolism of a therapeutic dose of45Ca in a case of multiple myeloma. Clin. Sci.15, 567–585 (1956).

    PubMed  Google Scholar 

  • —, andR. W. S. Tomlinson: The distribution of calcium-47 in the rat. J. Physiol.182, 664–670 (1966).

    PubMed  Google Scholar 

  • Anderson, J., R. W. S. Tomlinson, andS. B. Osborn: An interpretation of radioisotope turnover data. Lancet1962 I, 949–950.

  • Anderson, J., R. W. S. Tomlinson, S. B. Osborn, andM. E. Wise: Radiocalcium turnover in man. Lancet1967 I, 930–934.

  • —, andI. Weinbren: The determination of chromium and calcium in the faeces by flame spectrophotometer. Clin. Chim. Acta6, 648–651 (1961).

    PubMed  Google Scholar 

  • Aubert, J. P., F. Bronner, andL. J. Richelle: Quantitation of calcium metabolism. Theory. J. clin. Invest.42, 885–897 (1963).

    PubMed  Google Scholar 

  • Bauer, G. C. H., A. Carlsson, andB. Lindquist: Evaluation of accretion, resorption and exchange reactions in the skeleton. K. fysiogr. Sällsk. Lund. Förh.25, 1–16 (1955).

    Google Scholar 

  • —, andB. Wendeberg: External counting of Ca47 and Sr85 in studies of localised skeletal lesions in man. J. Bone Jt Surg. B41, 558–580 (1959).

    Google Scholar 

  • Corey, K. R., D. Weber, M. Merlino, E. Greenberg, P. Kenny, andJ. S. Laughlin: Calcium turnover in man. In: Dynamic clinical studies with radioisotopes, p. 519. (Ed.M. Knisely, W. N. Tauxe, andE. B. Anderson). USAEC, (1964).

  • Frost, H. M.: Bone dynamics in metabolic bone disease. J. Bone & Jt. Surg. A48, 1192–1203 (1966).

    Google Scholar 

  • Heaney, R. P., G. C. H. Bauer, F. Bronner, J. F. Dymling, F. W. Lafferty, B. E. C. Nordin, andC. Rich: A normal reference standard for radiocalcium turnover and excretion in humans. J. Lab. clin. Med.64, 21–28 (1964).

    PubMed  Google Scholar 

  • Lapiere, C. M., C. Onkelinx, andL. J. Richelle: Collagen metabolism in skin and bone. In: Biochemie et physiologie du tissu conjunctif, p. 505. (P. Comte, ed.) Sté Ormeco et Imprimerie du Sud-Est à Lyon (1966).

  • McIntyre, I.: The flame-spectrophotometric determination of calcium in biological fluids and an isotopic analysis of the errors in the Kramer-Tisdall procedure. Biochem. J.67, 164–172 (1957).

    PubMed  Google Scholar 

  • Marshall, J. H.: Theory of alkaline earth metabolism. Report ANL-6646, 5-29 USAEC (1963).

  • Marshall, J. H., R. E. Rowland, andJ. Jowsey: Microscopic metabolism of calcium in bone. V. The paradox of diffuse activity and long term exchange. Radiat. Res.10, 258–270 (1959).

    PubMed  Google Scholar 

  • Reifenstein, E. C., F. Albright, andS. L. Wells: The accumulation, interpretation and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus and nitrogen. J. clin. Endocrin.5, 367–395 (1945).

    Google Scholar 

  • Threefoot, S. A., C. T. Ray, G. E. Burch, J. Cronvitch, J. P. Milnor, W. Overman, andW. Gordon: Concentration-time course in the plasma of man of radiomercury introduced as a mercurial diuretic. J. clin. Invest.28, 661–670 (1949).

    Google Scholar 

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Tomlinson, R.W.S., Wall, M., Osborn, S.B. et al. Radiocalcium studies in normal subjects. Calc. Tis Res. 1, 197–203 (1967). https://doi.org/10.1007/BF02008091

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  • DOI: https://doi.org/10.1007/BF02008091

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