Abstract
We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10–100 μg/ml, without any apparent toxicity.
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Bianchi, M., Mantovani, A., Erroi, A. et al. Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells. Agents and Actions 31, 275–279 (1990). https://doi.org/10.1007/BF01997619
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DOI: https://doi.org/10.1007/BF01997619