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The effects of adenosine and of some adenosine analogues on the concanavalin A- or acetylcholine-induced histamine release from human adenoidal mast cells

  • Mechanisms of Histamine Release
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Abstract

Histamine release induced by concanavalin A (Con A) or acetylcholine is enhanced by adenosine or the adenosine analogues PIA and NECA. The enhancement is not affected by preincubation with adenosine deaminase.

The degree of the Con A-induced histamine release decreases with increasing incubation time. Under these conditions, the enhancing effect of adenosine on histamine release is either abolished or even reversed to inhibition.

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Authors and Affiliations

  1. Abteilung Pharmakologie, Medizinische Fakultät der RWTH, D-5100, Aachen

    K. Delmich, D. Eichelberg & W. Schmutzler

Authors
  1. K. Delmich
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  2. D. Eichelberg
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  3. W. Schmutzler
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Delmich, K., Eichelberg, D. & Schmutzler, W. The effects of adenosine and of some adenosine analogues on the concanavalin A- or acetylcholine-induced histamine release from human adenoidal mast cells. Agents and Actions 16, 141–143 (1985). https://doi.org/10.1007/BF01983122

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  • DOI: https://doi.org/10.1007/BF01983122

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