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Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats

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Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using AmesSalmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitrous acid produced from sodium nitrite and hydrogen ions. Sodium nitrite administered intracecally to 3 Wistar rats through surgically implanted cannula caused tumors (fibrosarcoma: 1/3 and squamous cell, 2/3). The possible role of nitrite-derived mutagens in GI cancer is discussed.

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Authors and Affiliations

  1. Departments of Medicine, Biochemistry and Pathology, Dalhousie Ůniversity, B3H4H7, Halifax, Nova Scotia, Canada

    I. A. Macdonald, J. A. Mader, B. G. Rao & D. A. Malatjalian

Authors
  1. I. A. Macdonald
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  2. J. A. Mader
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  3. B. G. Rao
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  4. D. A. Malatjalian
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Additional information

The authors are grateful to Dr A. Carl MacDonald of the Dept. of Surgery, Dalhousie University for his advice and encouragement in this project.

This work was supported by the National Cancer Institute of Canada.

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Macdonald, I.A., Mader, J.A., Rao, B.G. et al. Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats. Experientia 40, 554–557 (1984). https://doi.org/10.1007/BF01982327

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  • DOI: https://doi.org/10.1007/BF01982327

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