Abstract
Histamine inhibited luminol-dependent chemiluminescence (CL) of granulocytes in a dose-dependent manner, with an ID50 of about 3×10−5 M. Dimaprit, a selective H2-agonist, produced a histamine-like effect. Furthermore, cimetidine, ranitidine, and TZU 0460, which are selective H2-antagonists, but not mepyramine, a selective H1-antagonist, blocked the inhibitory effect of histamine on CL. Thus it may be concluded that the inhibitory effect of histamine is mediated via histamine H2-receptors. H1- and H2-antagonistsper se, except at extremely high concentrations, had no effect on CL of granulocytes.
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Ozaki, Y., Kume, S. & Ohashi, T. Effects of histamine agonists and antagonists on luminol-dependent chemiluminescence of granulocytes. Agents and Actions 15, 182–188 (1984). https://doi.org/10.1007/BF01972347
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DOI: https://doi.org/10.1007/BF01972347