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Modification of adjuvant inflammation in rats deficient in essential fatty acids

  • Immunosuppression and Inflammation
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Abstract

Rats deficient in essential fatty acids (EFA) did not develop as much foot swelling on receiving injections of complete Freund's adjuvant as did normal controls. Both the acute inflammation and the chronic inflammation were affected. This reduction in the chronic phase of adjuvant inflammation was restored to normal levels by feeding a small supplement of corn oil as a dietary source of EFA. Since the EFA are biologic precursors of prostaglandins (PG), the lack of EFA is thought to influence adjuvant-induced inflammation by reducing available PG mediators of inflammation.

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Authors and Affiliations

  1. Department of Medicine, Case Western Reserve University, and George H. Scott Research Laboratory, Fairview General Hospital, Cleveland, Ohio

    Charles W. Denko Ph.D., M.D.

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  1. Charles W. Denko Ph.D., M.D.
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Supported in part by a grant from the Arthritis Foundation, Northeast Ohio Chapter and a grant from Mrs Mildred Held.

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Denko, C.W. Modification of adjuvant inflammation in rats deficient in essential fatty acids. Agents and Actions 6, 636–641 (1976). https://doi.org/10.1007/BF01971583

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  • DOI: https://doi.org/10.1007/BF01971583

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