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Aspirin and prostaglandins: Some recent developments

  • Immunosuppression and Inflammation
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Abstract

The results of experiments designed to test the validity of the hypothesis that the anti-inflammatory and antirheumatic actions of aspirin are due to the inhibition of prostaglandin synthetase activity are reviewed.

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References

  1. S.H. Ferreira,Prostaglandins and Non-Steroidal Anti-Inflammatory Drugs, in:Prostaglandins and Thromboxanes (Eds. F. Berti, B. Samuelsson and G.P. Velo; Plenum Press, N.Y., 1977), pp. 353–361.

    Google Scholar 

  2. S. Moncada andJ.R. Vane,Interaction between Anti-Inflammatory Drugs and Inflammatory Mediators. A Reference to Products of Arachidonic Acid Metabolism, in:Inflammation: Mechanisms and their Impact on Therapy (Eds. I.L. Bonta, J. Thompson and K. Brune; Agents and Actions Supplements 3, Birkhäuser Verlag, Basel, 1977), pp. 141–148.

    Google Scholar 

  3. M.J.H. Smith,Prostaglandins and Aspirin: An Alternative View, Agents and Actions5, 315–317 (1975).

    PubMed  Google Scholar 

  4. P.L. Boardman andF.D. Hart,Clinical Measurements of the Anti-Inflammatory Effects of Salicylate in Rheumatoid Arthritis, Br. Med. J.4, 264–268 (1967).

    PubMed  Google Scholar 

  5. S.H. Ferreira andJ.R. Vane,New Aspects of the Mode of Action of Action of Non-Steroid Anti-Inflammatory Drugs, Ann. Rev. Pharmac.14, 57–71 (1974).

    Article  Google Scholar 

  6. D. Crook, A.J. Collins, P.A. Bacon andR. Chan,Prostaglandin Synthetase Activity from Human Rheumatoid Synovial Microsomes, Ann. Rheum. Dis.35, 327–332 (1976).

    PubMed  Google Scholar 

  7. B.B. Vargaftig,Salicylic Acid Fails to Inhibit Generation of Thromboxane A 2 Activity after in vivo Administration to the Rat, J. Pharm. Pharmac.30, 101–104 (1978).

    Google Scholar 

  8. A. Blackham andH. Radziwonik,The Effect of Drugs in Established Rabbit Monoarticular Arthritis, Agents and Actions7, 473–480 (1977).

    PubMed  Google Scholar 

  9. A. Blackham, J.B. Farmer, H. Radziwonik andJ. Westwick,The Role of Prostaglandins in Rabbit Monoarticular Arthritis, Br. J. Pharmac.51, 35–44 (1974).

    Google Scholar 

  10. B.B. Vargaftig,Platelets and Inflammation, in:Inflammation: Mechanisms and their Impact on Therapy (Eds. I.L. Bonta, J. Thompson and K. Brune; Agents and Actions Supplements 3, Birkhäuser Verlag, Basel, 1977), pp. 75–92.

    Google Scholar 

  11. A.L. Willis, R. Davison, P.W. Ramwell, W.D. Brocklehurst andB. Smith,Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs, in:Prostaglandins in Cellular Biology (Eds. P.W. Ramwell and B.B. Pharris; Plenum Press, N.Y., 1972), pp. 227–259.

    Google Scholar 

  12. G.A. Higgs, E.A. Harvey, S.H. Ferreira andJ.R. Vane,The Effects of Anti-Inflammatory Drugs on the Production of Prostaglandins in vivo, in:Advances in Prostaglandin and Thromboxane Research, vol. 1 (Eds. B. Samuelsson and R. Paoletti; Raven Press, N.Y., 1976), pp. 105–110.

    Google Scholar 

  13. G. Dipasquale andD. Mellace,Inhibition of Arachidonic Acid Induced Mortality in Rabbits with Several Non-Steroidal Anti-Inflammatory Agents, Agents and Actions7, 481–485 (1977).

    PubMed  Google Scholar 

  14. J.A. Sturman andM.J.H. Smith,The Binding of Salicylate to Plasma Proteins in Different Species, J. Pharmac. Pharmac.19, 621–623 (1967).

    Google Scholar 

  15. N.S. Doherty, M. Aattila andP.B. Dean,Penetration of Naproxen and Salicylate into Inflammatory Exudates in the Rat, Ann. Rheum. Dis.36, 244–248 (1977).

    PubMed  Google Scholar 

  16. M.J.H. Smith andP.D. Dawkins,Salicylate and Enzymes, J. Pharm. Pharmac.23, 729–744 (1971).

    Google Scholar 

  17. R.N. Pinckard, D. Hawkins andR.S. Farr,In vitro Acetylation of Plasma Proteins, Enzymes and DNA by Aspirin, Nature219, 68–69 (1968).

    PubMed  Google Scholar 

  18. T.Y. Shen,Prostaglandin Synthetase Inhibitors, in:Prostaglandins and Thromboxanes (Eds.F. Berti,B. Samuelsson andG.P. Velo; Plenum Press, N.Y., (1977), pp. 111–136.

    Google Scholar 

  19. D. Crook andA.J. Collins,Comparison of Effects of Aspirin and Indomethacin on Human Platelet Prostaglandin Synthetase, Ann. Rheum. Dis.36, 459–463 (1977).

    PubMed  Google Scholar 

  20. I.L. Bonta, H. Bult, J.E. Vincent andF.J. Zijlstra,Acute Anti-Inflammatory Effects of Aspirin and Dexamethazone in Rats Deprived of Endogenous Prostaglandin Precursors, J. Pharm. Pharmac.29, 1–7 (1977).

    Google Scholar 

  21. M.J.H. Smith, A.W. Ford-Hutchinson andP.N.C. Elliott,Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate, J. Pharm. Pharmac.27, 473–478 (1975).

    Google Scholar 

  22. J.R. Walker, M.J.H. Smith andA.W. Ford-Hutchinson,Anti-Inflammatory Drugs, Prostaglandins and Leucocyte Migration, Agents and Actions6, 602–606 (1976).

    PubMed  Google Scholar 

  23. A.W. Ford-Hutchinson, J.R. Walker, N.S. Connor, A.M. Oliver andM.J.H. Smith,Separate Anti-Inflammatory Effects of Indomethacin, Flurbiprofen and Benoxaprofen, J. Pharm. Pharmac.29, 372–373 (1977).

    Google Scholar 

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Smith, M.J.H. Aspirin and prostaglandins: Some recent developments. Agents and Actions 8, 427–429 (1978). https://doi.org/10.1007/BF01968670

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  • DOI: https://doi.org/10.1007/BF01968670

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