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Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse

  • Models of Inflammation and Arthritis
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Abstract

Zymosan, carrageenan, arachidonic acid and platelet activating factor (PAF) were used to induce inflammation (edema) in the paws of mice. Antiinflammatory drugs (e.g., BW755C and indomethacin) as well as cyproheptadine (mediator antagonist), theophylline (phosphodiesterase inhibitor) and guanabenz (α adrenoceptor agonist) showed the greatest efficacy in the carrageenan and zymosan models. Nonsteroidal antiinflammatory (NSAIDs) agents showed greater activity in the arachidonic acid (AA) paw edema model than the dual 5-lipoxygenase (LO)/cyclooxygenase (CO) inhibitors. The PAF model was insensitive to NSAIDs but showed some activity with drugs possessing inhibitory 5-LO activity (e.g., phenidone, BW755C) and the mediator antagonist, cyproheptadine. Suramin, a complement inhibitor, as expected, was active only against zymosan-induced edema. In conclusion, the inhibitory activities of dual 5-LO/CO inhibitors and NSAIDs were not different in the zymosan, carrageenan and AA edema models in the mouse; however, some selectivity for 5-LO inhibitors was observed in the PAF model.

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References

  1. A. W. Ford-Hutchinson, J. R. Walker, N. S. Connor and M. J. H. Smith,Prostaglandins and leukocyte migration in inflammatory reactions. Agents and Actions7, 469–472 (1977).

    PubMed  Google Scholar 

  2. C. A. Winter, E. A. Risley and G. W. Nuss,Carrageenan-induced edema in the hindpaw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med.111, 544–547 (1962).

    Google Scholar 

  3. C. G. Van Arman, A. J. Begany, L. M. Miller and H. H. Pless,Some details of the inflammations caused by yeast and carrageenan. J. Pharmacol. Exp. Ther.150, 328–334 (1965).

    Google Scholar 

  4. R. Vinegar, W. Schreiber and R. Hugo,Biphasic development of carrageenan edema in rats. J. Pharmacol. Exp. Ther.166, 96–103 (1969).

    PubMed  Google Scholar 

  5. J. Cottney, A. J. Lewis and D. J. Nelson,Arachidonic acid-induced paw edema in the rat. Br. J. Pharmacol.58, 311P (1976).

  6. M. M. Goldenberg and R. D. Meurer,A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat. Prostaglandins28, 271–278 (1984).

    Article  PubMed  Google Scholar 

  7. K. F. Swingle and M. J. Reiter,Inhibition of PAF-acether-induced edema of the rat's paw. Agents Actions18, 359–365 (1986).

    PubMed  Google Scholar 

  8. J. Damus and G. Remacle-Volon,Mast cell amines and the oedema induced by zymosan and carrageenans in rats. Eur. J. Pharmacol.121, 367–376 (1986).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Immunopharmacology Subdivision, Division of Experimental Therapeutics, Wyeth Laboratories, Inc., P.O. Box 8299, 19101, Philadelphia, PA, USA

    W. Calhoun, J. Chang & R. P. Carlson

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  1. W. Calhoun
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  2. J. Chang
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  3. R. P. Carlson
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Calhoun, W., Chang, J. & Carlson, R.P. Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse. Agents and Actions 21, 306–309 (1987). https://doi.org/10.1007/BF01966499

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  • DOI: https://doi.org/10.1007/BF01966499

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