Skip to main content
SpringerLink
Log in

Studies on the effect of polyamines and their products on Ehrlich ascites tumours

  • Histamine and Kinins
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Immobilized diamine oxidase injected into the peritoneal cavity of Swiss male mice 24 h after the viable intraperitoneal transplantation of Ehrlich ascites cells inhibits tumour growth.

This fact should be imputable to the oxidation of polyamines, originating from tumour cells, into aldehyde, the oxidation product.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. U. Bachrach, S. Abzug andA. Bekierkunst,Cytotoxic effect of oxidized spermine on Ehrlich ascites cells, Biochim. et Biophys. Acta134, 174–181 (1967).

    Google Scholar 

  2. M. Linde, G. Andersson andO. Heby,Putrescine administration reduces the rate of DNA synthesis in Ehrlich ascites tumour cells in vivo, Int. J. Biochem.12, 387–393 (1980).

    Article  PubMed  Google Scholar 

  3. J.M. Gaugas andD.L. Dewey,Evidence for serum binding of oxidized spermine and its potent G 1-phase inhibition of cell proliferation, Br. J. Cancer39, 548–557 (1978).

    Google Scholar 

  4. J.M. Gaugas andD.L. Dewey,Oxygen-dependent free radicals in spermine oxidation cytostasis and chemiluminescence and the role of superoxide dismutase, Br. J. Cancer41, 946–955 (1980).

    PubMed  Google Scholar 

  5. B. Mondovì, P. Guerrieri, M.T. Costa andS. Sabatini, Amine oxidase inhibitors and biogenic amine metabolism. InAdvances in Polyamine Research, vol. 3, pp. 75–84 (EdsC.M. Caldarera, V. Zappia andU. Bachrach), Raven Press, New York 1981.

    Google Scholar 

  6. J.R. Tennent,Evaluation of the trypan blue technique for determination of cell viability, Transplantation2, 685–694 (1964).

    Google Scholar 

  7. B. Mondovì, P. Guerrieri, A.M. Wolf, A. Ballini andP. Gerosa,Properties of immobilized histaminase, Agents and Actions,9, 40–41 (1979).

    PubMed  Google Scholar 

  8. B. Mondovì, A. Scioscia Santoro, R. Strom, F. Faiola andA. Rossi Fanelli,Increased immunogenicity of Ehrlich ascites cells after heat treatment, Cancer30, 885–888 (1972).

    PubMed  Google Scholar 

  9. U. Bachrach andS. Persky,Interaction of oxidized polyamines with DNA. V. Inhibition of nucleic acid synthesis, Biochim. Biophys. Acta179, 484–493 (1969).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Applied Biochemistry, University of Rome, Rome, Italy

    B. Mondovi

  2. CNR Centre of Molecular Biology, Rome, Italy

    P. Gerosa

  3. Regina Elena Institute for Cancer Research, Rome, Italy

    R. Cavaliere

Authors
  1. B. Mondovi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Gerosa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Cavaliere
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mondovi, B., Gerosa, P. & Cavaliere, R. Studies on the effect of polyamines and their products on Ehrlich ascites tumours. Agents and Actions 12, 450–451 (1982). https://doi.org/10.1007/BF01965925

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01965925

Keywords

Search

Navigation