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Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats

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Summary

Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.

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Authors and Affiliations

  1. Dept. Bioquímica, Facultad de Medicine, Av. Blasco Ibañez, 17, Valencia 10, Spain

    J. Viña, F. J. Romero, G. T. Saez & F. V. Pallardó

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  1. J. Viña
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  2. F. J. Romero
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  3. G. T. Saez
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  4. F. V. Pallardó
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Viña, J., Romero, F.J., Saez, G.T. et al. Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats. Experientia 39, 164–165 (1983). https://doi.org/10.1007/BF01958877

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  • DOI: https://doi.org/10.1007/BF01958877

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