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Biosynthetic relationships among daunorubicin, doxorubicin and 13-dihydrodaunorubicin inStreptomyces peucetius

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Summary

By feeding14C-daunorubicin to a doxorubicin-producing mutant ofStreptomyces peucetius, labelled doxorubicin and 13-dihydrodaunorubicin have been obtained; this indicates that the former compound is a precursor of both the latter ones in the fermentation process.

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Authors and Affiliations

  1. Farmitalia Carlo Erba S.p.A., Ricerca e Sviluppo di Microbiologia Industriale, via dei Gracchi 35, I-20146, Milano, Italy

    N. Crespi-Perellino, A. Grein, S. Merli, A. Minghetti & C. Spalla

Authors
  1. N. Crespi-Perellino
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  2. A. Grein
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  3. S. Merli
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  4. A. Minghetti
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  5. C. Spalla
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Crespi-Perellino, N., Grein, A., Merli, S. et al. Biosynthetic relationships among daunorubicin, doxorubicin and 13-dihydrodaunorubicin inStreptomyces peucetius. Experientia 38, 1455–1456 (1982). https://doi.org/10.1007/BF01955767

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  • DOI: https://doi.org/10.1007/BF01955767

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