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Potentiation of antifungal activity of sesquiterpene dialdehydes against Candida albicans and two other fungi

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Abstract

The antifungal activity of two drimane sesquiterpene dialdehydes, polygodial (1) and warburganal (2), alone and in combination with several other substances, was examined against three fungi,Candida albicans, Saccharomyces cerevisiae andPityrosporum ovale employing a broth dilution method. Anethole significantly synergized the activity of the two sesquiterpenoids againstC. albicans andS. cerevisiae however, it had only an, additive effect againstP. ovale. By contrast, two antioxidants, ascorbic acid (vitamin C) and BHA (butylated hydroxyanisole), noticeably enhanced the activity of the sesquiterpenoids againstP. ovale, but had no, effect againstC. albicans andS. cerevisiae.

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Authors and Affiliations

  1. Division of Entomology and Parasitology, College of Natural Resources, University of California, 94720, Berkeley, California, USA

    I. Kubo & M. Himejima

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  1. I. Kubo
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  2. M. Himejima
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Kubo, I., Himejima, M. Potentiation of antifungal activity of sesquiterpene dialdehydes against Candida albicans and two other fungi. Experientia 48, 1162–1164 (1992). https://doi.org/10.1007/BF01948015

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  • DOI: https://doi.org/10.1007/BF01948015

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