Summary
A direct relationship was established between the stability of the lysosomal membrane and an estimate of cytosolic protein catabolism, based on loss of radiolabel from prelabeled protein. Lysosomes in the lysosomally-rich digestive cells of the midgut gland of the marine mussel (Mytilus edulis) were destabilized by experimental treatment with phenanthrene.
References
Mortimore, G. E., Hutson, N. J., and Surmacz, C. A., Proc. natn. Acad. Sci. USA80 (1983) 2179.
Szego, C. M., in: Lysosomes in Biology and Pathology, vol. 4, p. 385. Eds J. T. Dingle and R. Dean. Elsevier, Amsterdam/New York/Oxford 1975.
Szego, C. M., and Pietras R. J., in: International Review of Cytology, vol. 88, p. 1. Eds G. H. Bourne, J. F. Danielli and K. W. Joen. Academic Press, New York/San Francisco/London 1984.
Bayne, B. L., Moore, M. N., and Koehn, R. K., Mar. Biol. Lett.2 (1981) 193.
Hawkins, H. K., in: Pathology of Cell Membranes, vol. 2, p. 252. Eds B. F. Trump and A. U. Arstila. Academic Press, New York/San Francisco/London 1980.
Pipe, R. K., and Moore, M. N., Mar. Biol.87 (1985) 157.
Sumner, A. T., J. Zool., London158 (1969) 277.
Owen, G., Sci. Prog. Oxford60 (1972) 319.
Moore, M. N., Mar. envir. Res.2 (1979) 255.
Moore, M. N., and Farrar, S. V., Mar. envir. Res.17 (1985) 222.
Moore, M. N., Lowe, D. M., and Fieth, P. E. M., Cell Tiss. Res.188 (1978) 1.
Moore, M. N., Lowe, D. M., and Fieth, P. E. M., Mar. Biol.48 (1978) 297.
Nelson, A., Mar. envir. Res.17 (1985) 306.
Livingstone, D. R., and Farrar, S. V., Sci. tot. Envir.39 (1984) 209.
Bitensky, L., Butcher, R. S., and Chayen, J., in: Lysosomes in Biology and Pathology, vol. 3, p. 465. Ed. J. T. Dingle. Elsevier, Amsterdam/New York/Oxford 1973.
Moore, M. N., Cell Tiss. Res.175 (1976) 279.
Waterlow, J. C., Garlick, P. J. and Milward, D. J., in: Protein Turnover in Mammalian Tissues and in the Whole Body, p. 371. North-Holland, Amsterdam/New York/Oxford 1978.
Yu, F. L., and Feigelson, P., Analyt. Biochem.39 (1971) 319.
Harthreee, E. F., Analyt. Biochem.48 (1972) 422.
Siegel, S., Nonparametric Statistics for the Behavioural Sciences. McGraw-Hill, New York 1956.
Lowe, D. M., and Moore, M. N., in: The Effects of Stress and Pollution on Marine Animals, p. 179. Eds B. L. Bayne et al. Praeger, New York 1985.
Viarengo, A., Moore, M.N., Pertica, M., and Mancinelli, G., Boll. Soc. ital. Biol. sperim.61 (1985) 69.
Livingstone, D.R., Widdows, J., and Fieth, P.E.M., Mar. Biol.53 (1979) 41.
Poste, G., and Allison, A. C., Biochim. biophys. Acta300 (1973) 421.
Bitensky, L., Alaghband-Zaden, J., and Chayen, J., Clin. Endocr.3 (1974) 363.
Neyland, D., and Smyth, P.P.A., Cell Biochem. Funct.1 (1983) 112.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moore, M.N., Viarengo, A. Lysosomal membrane fragility and catabolism of cytosolic proteins: evidence for a direct relationship. Experientia 43, 320–323 (1987). https://doi.org/10.1007/BF01945568
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01945568