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Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis

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Summary

A number of proteins, poly-L-amino acids, oligopeptides and lipids were tested for neutrophil, cosinophil and macrophage chemotactic activity. One myoglobin preparation was active. Based on the negative findings for all other substances, primary structure, secondary structure, degree of hydrophobicity, size and charge of a molecule, could be ruled out as structural features recognized by chemotactically responding phagocytes.

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References

  1. P. C. Wilkinson, in: Chemotaxis and inflammation. Churchill-Livingstone, Edinburgh 1974.

    Google Scholar 

  2. P. C. Wilkinson, Experientia28, 1051 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. M. Frimmer and B. Zweidler, Arch. exp. Path. Pharmak.251, 315 (1965).

    Article  CAS  Google Scholar 

  4. P. C. Wilkinson and I. C. McKay, Eur. J. Immun.2, 570 (1972).

    Article  CAS  Google Scholar 

  5. T. W. Jungi, Int. Archs Allergy48, 341 (1975).

    Article  CAS  Google Scholar 

  6. M. Frimmer and D. Hegner, Naunyn-Schmiedebergs Arch. Pharmak.245, 355 (1963).

    CAS  Google Scholar 

  7. D. B. Budzko, V. A. Bokisch and H. J. Müller-Eberhard, Biochemistry10, 1166 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. M. Liefländer, D. Dielenberg, G. Schmidt and W. Vogt, Hoppe-Seylers Z. Physiol. Chem.353, 385 (1972).

    Article  PubMed  Google Scholar 

  9. E. H. Vallota and H. J. Müller-Eberhard, J. exp. Med.137, 1109 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. J. Houck and C. Chang, Proc. Soc. exp. Biol. N. Y.138, 69 (1971).

    Article  CAS  Google Scholar 

  11. P. C. Wilkinson and I. C. McKay, Int. Arch. Allergy41, 237 (1971).

    Article  CAS  PubMed  Google Scholar 

  12. P. C. Wilkinson, Nature244, 512 (1973).

    Article  CAS  PubMed  Google Scholar 

  13. H. J. Showell, R. J. Freer, S. H. Zigmond, E. Schiffmann, S. Aswanikumar, B. Corcoran and E. L. Becker, J. exp. Med.143, 1154 (1976).

    Article  CAS  PubMed  Google Scholar 

  14. J. H. Wissler, V. J. Stecher and E. Sorkin, J. Immun.111, 314 (1973).

    Article  Google Scholar 

  15. A. P. Kaplan, A. B. Kay and K. F. Austen, J. exp. Med.135, 81 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. V. J. Stecher and E. Sorkin, in: Chemotaxis: Its Biology and Biochemistry, p. 362. Ed. E. Sorkin. Karger, Basel 1974.

    Google Scholar 

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Author notes

  1. T. W. Jungi

    Present address: James A. Baker Institute for Animal Health, New York State College for Veterinary Medicine, Cornell University, 14853, Ithaca, N. Y., USA

Authors and Affiliations

  1. Med. Abteilung, Schweiz. Forschungsinstitut, CH-7270, Davos, Switzerland

    T. W. Jungi

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  1. T. W. Jungi
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Additional information

I thank Dr J. H. Wissler for suggesting the reported experiments and Dr M. Landy and Prof. E. Sorkin for advice and criticism during preparation of this article. The excellent assistance by Mrs J. Kerschbaumer-Bech and Miss Margrit Bühlmann is gratefully acknowledged. This work was supported by Swiss National Foundation for Scientific Research, grant 3.8750.72, and by Sandoz-Stiftung, Basel.

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Jungi, T.W. Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis. Experientia 33, 95–97 (1977). https://doi.org/10.1007/BF01936774

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