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Gastric mucus effusion elicited by oral copper compounds: Potential anti-ulcer activity

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  • Biologica
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Summary

In rats, both Cu(I) and Cu(II) show an irritancy profile not shared with Cuo or Zn(II) or Ni(II). The gastric response to Cu(II), i.e. copius fluid and mucus secretion, can protect the stomach from the acute ulcerative effects of aspirin or physical stress administered subsequently.

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Author information

Author notes

  1. K. D. Rainsford

    Present address: Dept. of Biochemistry, University of Tasmania, 7001, Hobart, Australia

Authors and Affiliations

  1. Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, 2601, Canberra, A. C. T., Australia

    K. D. Rainsford & M. W. Whitehouse

Authors
  1. K. D. Rainsford
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  2. M. W. Whitehouse
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Additional information

to whom all enquiries should be addressed, Supported by grants from the National Health and Medical Research Council (Austr.) and University of Tasmania Research Commitee.

Acknowledgments: ProfessorsW. R. Walker (Newcastle, Austr.) andL. Field (Nashville, Tenn.) for gifts of Cu(I) and Zn complexes;Dr. J. R. J. Sorenson (Cincinnatti, Ohio) for illuminating discussion; Drs.D. D. Perrin (Canberra) andR. P. Agarwal (Washington D. C.) for providing stability constants and much helpful advice.

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Rainsford, K.D., Whitehouse, M.W. Gastric mucus effusion elicited by oral copper compounds: Potential anti-ulcer activity. Experientia 32, 1172–1173 (1976). https://doi.org/10.1007/BF01927608

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