Skip to main content
Log in

Nα-carbamoyl-2-O-methyltyrosine-oxytocin and 1–6α deamino cystathionine-2-O-methyltyrosine oxytocin: Two antagonists of oxytocin on amphibian epithelial cell receptors

  • Published:
Experientia Aims and scope Submit manuscript

Résumé

La Nα-Carbamoyl-2-O-Methyltyrosine ocytocine et la 1–6α déaminocystathionine 2-O-Methyltyrosine ocytocine inhibent les effets hydroosmotique (augmentation de la perméabilité osmotique à l'eau de la vessie de Grenouille) et natriférique (stimulation du transport actif de sodium par la peau) de l'ocytocine. L'inhibition observée est de nature compétitive. Les affinités respectives de ces deux analogues, exprimées en % de l'affinité de l'ocytocine, sont de 0,012 et 0,36 sur le test natriférique et de 0,11 et 1,1 sur le test hydroosmotique.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. J. Rudinger andI. Krejčf, Handb. exp. Pharmak.23, 748 (1968).

    Google Scholar 

  2. A. Chimiak, K. Eisler, K. Jost andRudinger, Colln Czech. chem. Commun.33, 2918 (1968).

    Article  CAS  Google Scholar 

  3. K. Jošt, in preparation.

  4. The authors are very much indebted to Dr.K. Jošt for his kind gift of the oxytocin analogues used in this study.

  5. J. Bourguet andS. Jard, Biochim. biophys. Acta88, 442 (1964).

    CAS  PubMed  Google Scholar 

  6. P. Eggena, I. L. Schwartz andR. Walter, J. gen. Physiol.52, 465 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. H. H. Ussing andZ. Zerahn, Acta physiol. scand.23, 110 (1951).

    Article  CAS  PubMed  Google Scholar 

  8. F. Morel, M. Odier etC. Lucarain, J. Physiol., Paris53, 757 (1961).

    CAS  PubMed  Google Scholar 

  9. J. Orloff andJ. S. Handler, J. clin. Invest.41, 702 (1962).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. F. Bastide andS. Jard, Biochim. biophys. Acta150, 113 (1968).

    Article  CAS  PubMed  Google Scholar 

  11. P. Eggena, I. L. Schwartz andR. Walter, J. gen. Physiol.56, 250 (1970).

    Article  CAS  PubMed Central  Google Scholar 

  12. S. Jard, R. M. Rajerison andM. Montegut, Biochim. biophys. Acta196, 85 (1970).

    Article  CAS  PubMed  Google Scholar 

  13. F. Morel andF. Bastide, in:Oxytocin, Vasopressin and their Structural Analogues (Ed.J. Rudinger; Pergamon Press, New York 1964), p. 47.

    Google Scholar 

  14. T. Barth, S. Jard, F. Morel andM. Montegut, in Experientia28, 967 (1972).

  15. I. Krejčí, in preparation.

Download references

Author information

Authors and Affiliations

Authors

Additional information

Fellowship supported by the Délégation Générale à la Recherche Scientifique et Technique.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barth, T., Jard, S., Morel, F. et al. Nα-carbamoyl-2-O-methyltyrosine-oxytocin and 1–6α deamino cystathionine-2-O-methyltyrosine oxytocin: Two antagonists of oxytocin on amphibian epithelial cell receptors. Experientia 28, 962–964 (1972). https://doi.org/10.1007/BF01924974

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01924974

Keywords

Navigation