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Tissue distribution and nucleic acid binding of chlorambuci-3H in tumor-bearing rats

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Summary

In tumour and normal rat tissues prolonged alkylation of DNA and RNA by chlorambucil-3H occurs over periods of 24 h. It is suggested that this may indicate the slow release of an alkylating moiety from an intracellular drugmacromolecule complex.

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Author notes

  1. K. D. Tew

    Present address: Department of Medical Oncology, Georgetown University, 3800 Reservoir Road, NW, 20007, Washington DC, USA

Authors and Affiliations

  1. Radiopharmacology Department, Institute of Cancer Research, SM2 5PT, Sutton, England

    K. D. Tew & D. M. Taylor

Authors
  1. K. D. Tew
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  2. D. M. Taylor
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Tew, K.D., Taylor, D.M. Tissue distribution and nucleic acid binding of chlorambuci-3H in tumor-bearing rats. Experientia 34, 1215–1216 (1978). https://doi.org/10.1007/BF01922965

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  • DOI: https://doi.org/10.1007/BF01922965

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