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Small lymphocyte production and lymphoid cell proliferation in mouse bone marrow

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Summary

In mice given3H-thymidine systemically during temporary circulatory occlusion of one hind limb, comparison of the labeling of rapidly-renewing small lymphocytes in the tibial marrows demonstrated that these cells were locally produced. Labeling by3H-thymidine infusion revealed that many marrow large lymphoid cells, presumptive small lymphocyte progenitors, had a marked proliferative activity and rapid turnover which varied according to cell size, was maximal in young mice and declined with increasing age.

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References

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Authors and Affiliations

  1. Department of Anatomy, McGill University, 3640, University Street, H3A 2B2, Montreal, Quebec, Canada

    S. C. Miller, M. Kaiserman &  D. G. Osmond

Authors
  1. S. C. Miller
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  2. M. Kaiserman
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  3. D. G. Osmond
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Additional information

This work was supported by a grant from the Medical Research Council of Canada. The technical assistance of Mrs E. D. Watson is acknowledged.

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Miller, S.C., Kaiserman, M. & Osmond, D.G. Small lymphocyte production and lymphoid cell proliferation in mouse bone marrow. Experientia 34, 129–131 (1978). https://doi.org/10.1007/BF01921944

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  • DOI: https://doi.org/10.1007/BF01921944

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