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Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells

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Summary

Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-aspirin, low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C.

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Authors and Affiliations

  1. Department of Kinesiology, Simon Fraser University, V5A 1S6, Burnaby 2, B.C., Canada

    E. S. Wilkins & M. G. Wilkins

Authors
  1. E. S. Wilkins
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  2. M. G. Wilkins
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Additional information

Acknowledgment. This work was supported by NRC grant No. A 6445 to Dr Bhakthan, Department of Kinesiology, Simon Fraser University.

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Wilkins, E.S., Wilkins, M.G. Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells. Experientia 35, 244–246 (1979). https://doi.org/10.1007/BF01920642

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  • DOI: https://doi.org/10.1007/BF01920642

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