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Biliary obstruction and susceptibility to biliary sepsis in rats

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Research in Experimental Medicine

Summary

The effect of retrograde intrabiliary (RI) injection ofE. coli was studied in Sprague-Dawley rats with biliary obstruction of different duration (3 days; 2, 4, and 6 weeks). By the injection of 105 colony-forming units (CFU) immediately after occlusion of the common bile duct (CBD), 15 of 18 normal rats survived without clinical signs of infection. In contrast, six of 11 animals in 3-day obstruction (P = 0.04), seven of 12 in 2-week obstruction (P = 0.02), ten of 12 in both 4-week and 6-week obstruction (P = 0.0004) died ofE. coli sepsis after injection of the same amount of bacteria. Animals with longstanding jaundice (4 and 6 weeks) were more susceptible than those with a shorter duration of jaundice (3 days and 2 weeks,P = 0.04). The results warrant the early decompression of the biliary tract in biliary obstruction.

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Authors and Affiliations

  1. Dept. of Surgery, University of Lund, S-221 85, Lund, Sweden

    N. Tanaka, S. Rydén, B. Klöfver-Ståhl & S. Bengmark

  2. Dept. of Microbiology, University of Lund, S-221 85, Lund, Sweden

    P. Christensen

Authors
  1. N. Tanaka
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  2. P. Christensen
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  3. S. Rydén
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  4. B. Klöfver-Ståhl
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  5. S. Bengmark
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Tanaka, N., Christensen, P., Rydén, S. et al. Biliary obstruction and susceptibility to biliary sepsis in rats. Res. Exp. Med. 185, 115–119 (1985). https://doi.org/10.1007/BF01854896

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  • DOI: https://doi.org/10.1007/BF01854896

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