Summary
Serum alpha-fetoprotein (AFP) concentrations increased promptly 2 days following a single injection of DL-ethionine (ethionine) in adult female rats. Continuous elevation of serum AFP was also observed on feeding a diet containing 1% ethionine for at least 2–3 weeks. A rise of serum AFP was not found if the diet was supplemented with 2.8% methionine. Furthermore, in rats fed on 1% ethionine for 2 weeks, dietary change to the laboratory chow supplemented with and without 2.8% methionine produced a decrease of increased serum AFP levels.
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References
Becker FF, Sell S (1974) Early elevation ofα 1-fetoprotein in N-2-fluorenylacetamide hepatocarcinogenesis. Cancer Res 34:2489–2494
Belanger L, Hamel D, Lachance L, Dufour D, Tremblay M, Gagnon PM (1975) Hormonal regulation ofα 1-fetoprotein. Nature 256:657–659
Belanger L, Larochelle L, Belanger M, Prive L (1976) Tyrosinosis: Hereditary persistence ofα 1-fetoprotein. In: Fishman WH, Sell S (eds) Onco-developmental gene expression. Academic Press, New York, p 155
Farber E (1956) Carcinoma of the liver in rats fed ethionine. AMA Arch Pathol 62:445–453
Foy H, Kondi A, Davies JNP, Anderson B, Parker A, Preston J, Peers FG (1974) Histological changes in liver of pyridoxine-deprived baboons — Relation toα 1-fetoprotein and liver cancer in Africa. J Natl Cancer Inst 53:1295–1311
Hancock RL, Forrester PI, Lorscheider FL, Lai PCW, Hay DM (1976) Ethionine-induced activation of embryonic genes. In: Fishman WH, Sell S (eds) Onco-developmental gene expression. Academic Press, New York, p 247
Kitagawa T, Yokochi T, Sugano H (1972)α-Fetoprotein and hepatocarcinogenesis in rats fed 3′-methyl-4-(dimethylamino)-azobenzene or N-2-fluorenylacetamide. Int J Cancer 10:368–381
Kroes R, Williams GM, Weisburger JH (1973) Early appearance of serumα-fetoprotein as a function of dosage of various hepatocarcinogens. Cancer Res 33:613–617
McIntire KR, Vogel LL, Princler GL, Patel IR (1972) Serumα-fetoprotein as a biochemical marker for hepatocellular carcinoma. Cancer Res 32:1941–1946
Miyazaki M, Watanabe A, Taketa K, Sato J (1976) Prompt elevation of rat serumα-fetoprotein by ethionine-induced acute liver injury and its electrophoretic properties (in Japanese). Physico-Chem Biol 20:251–256
Smuckler EA, Koplitz RM, Sell S (1976) Alpha-fetoprotein responses following phenobarbital stimulation of rat liver. In: Fishman WH, Sell S (eds) Onco-developmental gene expression. Academic Press, New York, p 253
Stramentinoli G, Pezzoli C, Catto E (1975) Pharmacological aspects of S-adenosylmethionine in hepatology. Minn Med 66:1541–1549
Tumyan BG, Svet-Moldavsky GG, Karmanova NV (1975) Factor suppressing alpha-fetoprotein production in newborn mice. Nature 255:244–245
Watabe H (1971) Early appearance of embryonicα-globulin in rat serum during carcinogenesis with 4-dimethylamino-azobenzene. Cancer Res 31:1192–1194
Watanabe A, Miyazaki M, Taketa K (1976) Prompt elevation of rat serumα-fetoprotein by acute liver injury following a single injection of ethionine. Int J Cancer 17:518–524
Watanabe A, Miyazaki M, Taketa K (1976) Increasedα 1-fetoprotein production in rat liver injuries induced by various hepatotoxins. Gann 67:279–287
Watanabe A, Miyazaki M, Nagashima H (1979) Effect of pyridoxine-adenosine 5′-triphosphate and S-adenosyl-methionine on increased alpha-fetoprotein synthesis by hepatic injury. In: Lehmann FG (ed) Carcino-embryonic proteins. Chemistry, biology, clinical application, vol II. Elsevier/North-Holland Biomedical Press, Amsterdam New York Oxford, p 231
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Miyazaki, M., Watanabe, A., Wahid, S. et al. Influence of methionine administration on serum alpha-fetoprotein levels in ethionine-injured rats. Res. Exp. Med. 180, 15–19 (1982). https://doi.org/10.1007/BF01852227
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DOI: https://doi.org/10.1007/BF01852227