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Melanoma and sunburn

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Abstract

A computer-aided search identified 16 case-control studies which specifically assessed sunburn as a risk factor for cutaneous malignant melanoma. Using unadjusted estimates, a history of sunburn was associated with significantly increased risk of melanoma in all but one study. Four studies were defined as core studies after assessment of study quality; however, only two of these had sufficiently similar definitions of sunburn to allow pooling of results. Using pooled data, the risk of melanoma in those ever sunburned was 2.0 (95 percent confidence interval [CI]=1.6–2.6), while the highest category of sunburn exposure had a risk of 3.7 (CI=2.5–5.4). The suggestion that sunburns in childhood carry greater risk of melanoma cannot be supported by pooled analysis. This review demonstrated considerable variation in design and method among the studies, and identified sources of bias which prevented a pooled analysis using all available data. The need for strong epidemiologic evidence relating sunburn to melanoma, particularly in childhood, is of prime importance, since avoidance of sunburn is one of the few potential means of primary prevention of melanoma.

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References

  1. Osterlind A, Hou-Jensen K, Moller Jensen O. Incidence of cutaneous malignant melanoma in Denmark 1978–1982. anatomic site distribution, histologic types, and comparison with non-melanoma skin cancer.Br J Cancer 1988;58: 385–91.

    PubMed  Google Scholar 

  2. Thörn M, Bergström R, Adami HO, Ringborg U. Trends in the incidence of malignant melanoma in Sweden, by anatomic site, 1960–1984.Am J Epidemiol 1990;132: 1066–77.

    PubMed  Google Scholar 

  3. Koh HK, Clapp RW, Barnett JM,et al. Systematic underreporting of cutaneous malignant melanoma in Massachusetts.J Am Acad Dermatol 1991;24: 545–50.

    PubMed  Google Scholar 

  4. Skolnick AA. Melanoma epidemic yields grim statistics.JAMA 1991;265: 3217–8.

    Google Scholar 

  5. McHenry PM, Hole DJ, MacKie R. Melanoma in people aged 65 and over in Scotland, 1979–89.Br Med J 1992;304: 746–9.

    Google Scholar 

  6. Cooke K, McNoe B, Hursthouse M, Taylor R. Primary malignant melanoma of skin in four regions of New Zealand.NZ Med J 1992;105: 303–6.

    Google Scholar 

  7. MacLennan R, Green AC, McLeod GRC, Martin NG. Increasing incidence of cutaneous melanoma in Queensland, Australia.JNCI 1992;84: 1427–32.

    PubMed  Google Scholar 

  8. McGovern VJ. Melanoblastoma.Med J Aust 1952,i: 139–42.

    Google Scholar 

  9. Lancaster HO. Some geographical aspects of the mortality from melanoma in Europeans.Med J Aust 1956;i: 1082–7.

    Google Scholar 

  10. Elwood JM. Recent developments in melanoma epidemiology, 1993.Melanoma Res 1993;3: 149–56.

    PubMed  Google Scholar 

  11. Cavallo J, DeLeo VA. Sunburn.Dermatol Clinics 1986;4: 181–7.

    Google Scholar 

  12. Viscoli CM, Lachs MS, Horwitz RI. Bladder cancer and coffee drinking: a summary of case-control research.Lancet 1993;341: 1432–7.

    PubMed  Google Scholar 

  13. Holman CD, Armstrong BK. Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: An analysis separating histogenetic types.JNCI 1984;73: 75–82.

    PubMed  Google Scholar 

  14. Marshman G, Kennedy C. Acral lentiginous melanoma.Br J Dermatol 1991;125 (Suppl): 96.

    Google Scholar 

  15. Centers for Disease Control.Epilnfo Version 5.01a. Atlanta, GA (USA): Public Domain Software, CDC Epidemiology Program Office, 1991.

    Google Scholar 

  16. Mantel N, Haenzel W. Statistical aspects of the analysis of data from retrospective studies of disease.JNCI 1959;22: 719–48.

    PubMed  Google Scholar 

  17. Breslow NE, Day NE.Statistical Methods in Cancer Research. Vol I. The Analysis of Case-control Studies. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Publ. No. 32.

    Google Scholar 

  18. MacKie RM, Aitchison T. Severe sunburn and subsequent risk of primary cutaneous malignant melanoma in Scotland.Br J Cancer 1982;46: 955–60.

    PubMed  Google Scholar 

  19. Lew RA, Sober AJ, Cook N, Marvell R, Fitzpatrick TB. Sun exposure habits in patients with cutaneous melanoma: a case control study.J Dermatol Surg Oncol 1983;9: 981–6.

    PubMed  Google Scholar 

  20. Elwood JM, Gallagher RP, Davison J, Hill GB. Sunburn, suntan and the risk of cutaneous malignant melanoma—The Western Canada Melanoma Study.Br J Cancer 1985;51: 543–9.

    PubMed  Google Scholar 

  21. Elwood JM, Gallagher RP, Hill GB, Spinelli JJ, Pearson JCG, Threlfall W. Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada Melanoma Study.Br Med J 1984;288: 99–102.

    Google Scholar 

  22. Sorahan T, Grimley RP. The aetiological significance of sunlight and fluorescent lighting in malignant melanoma: a case-control study.Br J Cancer 1985;52: 765–9.

    PubMed  Google Scholar 

  23. Green A, Siskind V, Bain C, Alexander J. Sunburn and malignant melanoma.Br J Cancer 1985;51: 393–7.

    PubMed  Google Scholar 

  24. Holman CD, Armstrong BK, Heenan PJ. Relationship of cutaneous malignant melanoma to individual sunlight-exposure habits.JNCI 1986;76: 403–14.

    PubMed  Google Scholar 

  25. Elwood JM, Whitehead SM, Davison J, Stewart M, Galt M. Malignant melanoma in England: risks associated with naevi, freckles, social class, hair color, and sunburn.Int J Epidemiol 1990;19: 801–10.

    PubMed  Google Scholar 

  26. Cristofolini M, Franceschi S, Tasin L,et al. Risk factors for cutaneous malignant melanoma in a northern Italian population.Int J Cancer 1987;39: 150–4.

    PubMed  Google Scholar 

  27. Holly EA, Kelly JW, Shpall SN, Chiu SH. Number of melanocytic nevi as a major risk factor for malignant melanoma.J Am Acad Dermatol 1987;17: 459–68.

    PubMed  Google Scholar 

  28. Osterlind A, Tucker MA, Stone BJ, Jensen OM. The Danish case-control study of cutaneous malignant melanoma II. Importance of UV-light exposure.Int J Cancer 1988;42: 319–24.

    PubMed  Google Scholar 

  29. Dubin N, Moseson M, Pasternack BS. Sun exposure and malignant melanoma among susceptible individuals.Environ Health Perspect 1989;81: 139–51.

    PubMed  Google Scholar 

  30. Beitner H, Norell SE, Ringborg U, Wennersten G, Mattson B. Malignant melanoma: aetiological importance of individual pigmentation and sun exposure.Br J Dermatol 1990;122: 43–51.

    Google Scholar 

  31. Elwood JM, Williamson C, Stapleton PJ. Malignant melanoma in relation to moles, pigmentation, and exposure to fluorescent and other lighting sources.Br J Cancer 1986;53: 65–74.

    PubMed  Google Scholar 

  32. Zanetti R, Franceschi S, Rosso S, Colonna S, Bidoli E. Cutaneous melanoma and sunburns in childhood in a southern European population.Eur J Cancer 1992;28A: 1172–6.

    PubMed  Google Scholar 

  33. Dunn-Lane J, Herity B, Moriarty MJ, Conroy R. A case-control study of malignant melanoma.Ir Med J 1993;86: 57–9.

    PubMed  Google Scholar 

  34. Weinstock MA, Colditz GA, Willett WC,et al. Non-familial cutaneous melanoma incidence in women associated with sun exposure before 20 years of age.Pediatrics 1989;84: 199–204.

    PubMed  Google Scholar 

  35. Wacholder S, McLaughlin JK, Silverman DT, Mandel JS. Selection of controls in case-control studies I. Principles.Am J Epidemiol 1992;135: 1019–28.

    PubMed  Google Scholar 

  36. Weinstock MA, Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE. Recall (report) bias and reliability in the retrospective assessment of melanoma risk.Am J Epidemiol 1991;133: 240–5.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Epidemiology Unit, Queensland Institute of Medical Research, 300 Herston Road, 4029, Herston, Queensland, Australia

    David Whiteman &  Adèle Green

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  1. David Whiteman
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  2. Adèle Green
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Whiteman, D., Green, A. Melanoma and sunburn. Cancer Causes Control 5, 564–572 (1994). https://doi.org/10.1007/BF01831385

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