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Relationship among estrogen receptors, proliferative activity and menopausal status in breast cancer

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Summary

Kinetic and estrogen receptor (ER) determinations were performed on 357 primary breast cancers. The proliferative activity of the cell population was determined by the autoradiographic technique and expressed as [3H]thymidine labeling index (LI); the ER status was assessed by the absorption charcoal technique. From the overall analysis of the relationship between proliferative activity and ER status, by using the median LI value as cutoff of low and high proliferating tumors, a correlation between ER + status and low proliferative activity and between ER-status and high proliferative activity was observed in 64% of the cases. Menopausal status proved to be an important determinant of kinetic and ER features. In fact, the proliferative activity was always higher in ER − tumors than in ER + tumors within the same menopausal group, and a decrease in proliferative activity was observed from premenopause to postmenopause within ER + and ER − tumors. The analysis of the relation between ER levels and proliferative activity in ER + tumors also evidenced three main ER/LI clusters significantly related to premenopause, paramenopause and postmenopause. A particular indication of nodal involvement was evidenced for a cluster of tumors with low ER levels and high LI from postmenopausal patients. The three different, previously proposed kinetic groups of potential relevance for prognostic and therapeutic purposes were confirmed and more precisely defined by considering not only premenopause and postmenopause but also paramenopause.

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References

  1. McGuire WL: Hormone receptors: Their role in predicting prognosis and response to endocrine therapy. Semin Oncol 5: 428–433, 1978

    PubMed  Google Scholar 

  2. McGuire WL (ed): Progress in Cancer Research and Therapy. X. Hormones, receptors and breast cancer. Raven Press, New York, 1978

    Google Scholar 

  3. Lippman ME, Allegra JC, Thompson EB, Simon R, Barlock A, Green L, Huff KK, Do HMT, Aitken SC, Warren R: The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N Engl J Med 298: 1223–1228, 1978

    PubMed  Google Scholar 

  4. Kiang DT, Frenning DH, Goldman AI, Ascensao VF, Kennedy BJ: Estrogen receptors and responses to chemotherapy and hormonal therapy in advanced breast cancer. N Engl J Med 299: 1330–1334, 1978

    PubMed  Google Scholar 

  5. Bonadonna G, Valagussa P, Tancini G, Di Fronzo G: Estrogen-receptor status and response to chemotherapy in early and advanced breast cancer. Cancer Chemother Pharmacol 4: 37–41, 1980

    PubMed  Google Scholar 

  6. Carter SK: The dilemma of estrogen receptors and the response rate to cytotoxic chemotherapy. A problem of comparability analysis. Cancer Clin Trials 2: 49–53, 1979

    PubMed  Google Scholar 

  7. Cooke T, George D, Shields R: Oestrogen receptors and prognosis in early breast cancer. Lancet 1: 995–997, 1979

    PubMed  Google Scholar 

  8. Valagussa P, Di Fronzo G, Bignami P, Buzzoni R, Bonadonna G, Veronesi U: Prognostic importance of estrogen receptors to select node-negative patients for adjuvant chemotherapy,In SE Jones and SE Salmon (eds): Adjuvant Therapy of Cancer, 3rd ed. Grune & Stratton, New York, 1981 (in press)

    Google Scholar 

  9. Hähnel R, Woodings T, Vivian AB: Prognostic value of estrogen receptors in primary breast cancer. Cancer 44: 671–675, 1979

    PubMed  Google Scholar 

  10. Hilf R, Feldstein ML, Gibson SL, Savlov ED: The relative importance of estrogen receptor analysis as a prognostic factor for recurrence or response to chemotherapy in women with breast cancer. Cancer 45: 1993–2000, 1980

    PubMed  Google Scholar 

  11. Allegra JC, Lippman ME: Estrogen receptor status and the disease-free interval in breast cancer. Recent Results Cancer Res 71: 20–25, 1980

    PubMed  Google Scholar 

  12. Meyer JS, Hixon B: Advanced stage and early relapse of breast carcinomas associated with high thymidine labeling indices. Cancer Res 39: 4042–4047, 1979

    Google Scholar 

  13. Gentili C, Sanfilippo O, Silvestrini R: Cell proliferation in relation to clinical features and relapse in breast cancer. Cancer (in press)

  14. Meyer JS, Rao BR, Stevens SC, White WL: Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication. Cancer 40: 2290–2298, 1977

    PubMed  Google Scholar 

  15. Silvestrini R, Daidone MG, Di Fronzo G: Relationship between proliferative activity and estrogen receptors in breast cancer. Cancer 44: 665–670, 1979

    PubMed  Google Scholar 

  16. Kiang DT, Kennedy BJ: Factors affecting estrogen receptors in breast cancer. Cancer 40: 1571–1576, 1977

    PubMed  Google Scholar 

  17. Polvani F, Silvestrini R: Note di tecnica autoradiografica con pellicole ‘stripping’. Riv Istochim Norm Patol 2: 239–256, 1956

    Google Scholar 

  18. EORTC Breast Cancer Cooperative Group: Standards for the assessment of estrogen receptors in human breast cancer. Eur J Cancer 9: 379–381, 1973

    Google Scholar 

  19. Scatchard G: The attractions of protein for small molecules and ions. Ann N Y Acad Sci 51: 660–672, 1949

    Google Scholar 

  20. Di Fronzo G, Bertuzzi A, Ronchi E: An improved criterion for the evaluation of estrogen receptor binding data in human breast cancer. Tumori 64: 259–266, 1978

    PubMed  Google Scholar 

  21. Berge C: The Theory of Graphs. Wiley Methuen, Paris, 1958, pp 58–77

    Google Scholar 

  22. Ore O: Theory of Graphs. American Mathematical Society, Rhode Island, 1963, pp 152–164

    Google Scholar 

  23. Basagni ML, Nuvolari J, Sciacchitano A: Algoritmi di classificazione automatica,In Informatica, Biometria e Statistica Medica. Monograph by ‘Centro G. Zambon’ and Institute of Biometry and Medical Statistics, Faculty of Medicine and Surgery, University of Milan, Italy, 1970, pp 81–87

    Google Scholar 

  24. Lachenbruch PA, Goldstein M: Discriminant analysis. Biometrics 35: 69–85, 1979

    Google Scholar 

  25. Nenci I: Receptor and centriole pathways of steroid action in normal and neoplastic cells. Cancer Res 38: 4204–4211, 1978

    PubMed  Google Scholar 

  26. Nomura Y, Yamagata J, Kondo H, Kanda K, Takenaka K: Clinical usefulness of estrogen receptor assay in early and advanced breast cancer,In WL McGuire (ed): Hormones, Receptors and Breast Cancer. Raven Press, New York, 1978, pp 15–29

    Google Scholar 

  27. Di Fronzo G, Bertuzzi A, Saccozzi R: Clinical data and estradiol receptor evaluation in breast cancer biopsies. Tumori 65: 221–228, 1979

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

    Armando Bertuzzi, Maria Grazia Daidone, Giovanni Di Fronzo & Rosella Silvestrini

Authors
  1. Armando Bertuzzi
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  2. Maria Grazia Daidone
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  3. Giovanni Di Fronzo
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  4. Rosella Silvestrini
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Address for reprints: Prof. R. Silvestrini, Istituto Nazionale Tamori, Via Venezian 1, 20133 Milan, Italy.

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Bertuzzi, A., Daidone, M.G., Fronzo, G.D. et al. Relationship among estrogen receptors, proliferative activity and menopausal status in breast cancer. Breast Cancer Res Tr 1, 253–262 (1981). https://doi.org/10.1007/BF01806265

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