Abstract
TR81 is a specificity closely related to or identical with DR3. In Caucasoids two amino acids, Tyr at position 26 and Arg at position 74 of HLA class II DRβ chains, have been found to be associated with the presence of TR81. Recently, a variant of DRBI *03 identified in American Blacks has been shown to possess Arg at position 74 but Phe at position 26. This codon combination is found to be present in four other cell lines where it still specifies the TR81 determinant. This suggests that the TR81 specificity is uniquely dependent on the presence of Arg at position 74.
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Sorrentino, R., Iannicola, C., Costanzi, S. et al. Arg74 in HLA-DRBI and DRB3 controls a DR3-related epitope. Immunogenetics 32, 8–12 (1990). https://doi.org/10.1007/BF01787322
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DOI: https://doi.org/10.1007/BF01787322