References
Arathoon WR, Birch JR (1986) Large Scale Cell Culture in Biotechnology. Science 232:1390–1395
Mann KG, Fass DN (1983) The Molecular Biology of Blood Coagulation in Current Hematology, Volume 2, Virgil F Fair-banks (ed). John Wiley & Sons Inc.
Kaufman RJ, Wasley LC, Davies MV, Wise RJ, Israel DI, Dorner AJ (1989) Effect of von Willebrand Factor Coexpression on the Synthesis and Secretion of Factor VIII in Chinese Hamster Ovary Cells. Mol Cell Biol 9:1233–1242
Kaufman RJ, Wasley LC, Dorner AJ (1988) Synthesis, Processing, and Secretion of Recombinant Human Factor VIII Expressed in Mammalian Cells. J Biol Chem 263:6352–6362
Pittman DD, Kaufman RJ (1988) Proteolytic Requirements for Thrombin Activation of Anti-hemophilic Factor (Factor VIII). Proceedings of the National Academy of Science (USA) 85:2429–2433
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Adamson, R. Design and operation of a recombinant mammalian cell manufacturing process for rFVIII. Ann Hematol 68 (Suppl 3), S9–S14 (1994). https://doi.org/10.1007/BF01774523
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DOI: https://doi.org/10.1007/BF01774523