Skip to main content
SpringerLink
Log in

Analysis of natural killer activity and natural killer cell subsets in patients with bladder cancer

  • Original articles
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Summary

In order to analyze the state of the natural resistance system of bladder cancer patients in vivo, we measured natural killer (NK) activity and NK cell subsets of peripheral blood lymphocytes (PBL) from 46 patients with bladder cancer and 25 age- and sex-matched healthy volunteers. The mean NK activity in patients with lowstage bladder cancer was similar to that in the controls, while NK activity in patients with high-stage bladder cancer was significantly depressed. The mean proportions of Leu7+ cells in patients with both low-stage and highstage bladder cancer were significantly higher than that in the controls. The mean proportion of Leu11a+ cells in patients with low-stage bladder cancer was similar to that in the controls, while in patients with high-stage bladder cancer it was significantly higher. This study demonstrates the abnormal immunological state of bladder cancer patients; namely, abnormalities exist not only in NK activity but also in the proportions of circulating NK cell subsets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abo T, Miller CA, Gartland GL, Balch CM (1983) Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. J Exp Med 157: 273

    PubMed  Google Scholar 

  2. Balch CM, Tilden AB, Dougherty PA, Cloud GA, Abo T (1983) Depressed levels of granular lymphocytes with natural killer (NK) cell function in 247 cancer patients. Ann Surg 198: 192

    PubMed  Google Scholar 

  3. Britten V, Rees RC, Clegg A, Smith GT, Potter CW, Fox M, Williams JL (1982) Natural killer cell activity and response to phytohaemagglutinin compared with the histological diagnosis of patients with transitional cell carcinoma of the bladder. Br J Urol 54: 261

    PubMed  Google Scholar 

  4. Catalona WJ, Tarpley JL, Chretien PB, Castle JR (1974) Lymphocyte stimulation in urologic cancer patients. J Urol 112: 373

    PubMed  Google Scholar 

  5. Herberman RB, Ortaldo JR (1981) Natural killer cells: Their role in defenses against disease. Science 214: 24

    PubMed  Google Scholar 

  6. Lanier LL, Le AM, Phillips JH, Warner NL, Babcock GF (1983) Subpopulations of human natural killer cells defined by expression of the Leu7 (HNK-1) and Leu11 (NK-15) antigens. J Immunol 131: 1789

    PubMed  Google Scholar 

  7. Lanier LL, Cwirla S, Federspiel N, Phillips JH (1986) Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor chain genes. J Exp Med 163: 209

    PubMed  Google Scholar 

  8. Ma CP, Yu DS, Yeh MY, Chang SY, Han SH (1987) Natural killer cell activity in patients with urologic cancer. Eur Urol 13: 397

    PubMed  Google Scholar 

  9. Marshall VF (1952) The relation to the preoperative estimate to the pathologic demonstration of the extent of vesical neoplasms. J Urol 68: 714

    PubMed  Google Scholar 

  10. Minato N, Bloom BR, Jones C, Holland J, Reid LM (1979) Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice. J Exp Med 149: 1117

    PubMed  Google Scholar 

  11. Minato N, Reid L, Bloom BR (1981) On the heterogeneity of murine natural killer cells. J Exp Med 154: 750

    PubMed  Google Scholar 

  12. Morales A, Ottenhof PC (1983) Clinical application of a whole blood assay for human natural killer (NK) cell activity. Cancer 52: 667

    PubMed  Google Scholar 

  13. Morita T, Yonese Y, Minato N (1987) Evaluation of lymphocyte subpopulations in patients with bladder cancer: a study with monoclonal antibodies. Acta Urol Jpn 33: 838

    Google Scholar 

  14. Olsson CA, Rao CN, Menzoian JO, Byrd WE (1972) Immunologic unreactivity in bladder cancer patients. J Urol 107: 607

    PubMed  Google Scholar 

  15. Polli N, Matutes E, Robinson D, Catovsky D (1987) Morphological heterogeneity of Leu7, Leu11 and OKM1 positive lymphocyte subsets: an ultrastructural study with the immunogold method. Clin Exp Immunol 68: 331

    PubMed  Google Scholar 

  16. Saksela E, Tarkkanen J, Carpen O, Virtanen J (1982) Morphological and functional characteristics of human NK system. In: Serrou B, Rosenfeld C, Herberman RB (eds) Human cancer immunology: natural killer cells. Elsevier Biomedical Press, New York, pp 81–82

    Google Scholar 

  17. Schantz SP, Shillitoe EJ, Brown B, Campbell B (1986) Natural killer cell activity and head and neck cancer: a clinical assessment. J Natl Cancer Inst 77: 869

    PubMed  Google Scholar 

  18. Steinhauer EH, Doyle AT, Reed J, Kadish AS (1982) Defective natural cytotoxicity in patients with cancer: normal number of effector cells but decreased recycling capacity in patients with advanced disease. J Immunol 129: 2255

    PubMed  Google Scholar 

  19. Takasugi M, Ramseyer A, Takasugi J (1977) Decline of natural non-selective cell mediated cytotoxicity in patients with tumor progression. Cancer Res 37: 413

    PubMed  Google Scholar 

  20. UICC: Union Internationale Contre le Cancer (1978) TNM classification of malignant tumours. 3rd edn, International Union Against Cancer, Geneva

    Google Scholar 

  21. Zagury D, Morgan DA, Fouchard M, Bernard J, Feldman M, Herberman RB (1985) Heterogeneity of human natural killer cells. J Natl Cancer Inst 74: 553

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, 32 904, Tochigi, Japan

    Tatsuo Morita & Akihiko Tokue

  2. Department of Medicine, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, 32 904, Tochigi, Japan

    Nagahiro Minato

Authors
  1. Tatsuo Morita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akihiko Tokue
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nagahiro Minato
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morita, T., Tokue, A. & Minato, N. Analysis of natural killer activity and natural killer cell subsets in patients with bladder cancer. Cancer Immunol Immunother 32, 191–194 (1990). https://doi.org/10.1007/BF01771456

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01771456

Keywords

Search

Navigation