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Intrakranielle und intraspinale Blutungen unter Behandlung mit Cumarinderivaten

Intracranial and intraspinal bleedings in patients under coumarin derivatives

Katamnese von 63 Fällen zwischen 1978 und 1986

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Summary

From 1978–1986, 63 patients (48–79 years) under coumarin derivatives had to be hospitalized neurosurgically because of intrcranial or intraspinal bleedings. This corresponds to a twelvefold increased risk compared to the untreated people. The male/female ratio was 1.5. At the time of the bleeding there was no true indication for anticoagulation in at least 60% of the patients. 80% with coma on admission died. Only for 2/7 with an intraspinal hemorrhage the outcome was better than paraplegic. Women proved to have a better chance of survival. — There is a need for more concise indications for chronic anticoagulation.

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Abbreviations

CT:

Röntgen-Computertomographie

„Cumarine“:

für Cumarinderivate; hier zu 97% Phenprocoumon

„ZNS“-Blutung:

nur der Kürze wegen fürbegrifflich korrekt: „intrakranielle und intraspinale“ Blutung

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Authors and Affiliations

  1. Neurochirurgische Universitätsklinik, Germany

    D. Moskopp

  2. Neuroradiologische Abteilung der Neurochirurgischen Universitätsklinik, Germany

    F. Brassel

  3. Universitäts-Nervenklinik — Neurologie Rheinische-Friedrich-Wilhelms-Universität Bonn, Germany

    F. Ries

Authors
  1. D. Moskopp
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  2. F. Brassel
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  3. F. Ries
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Meinem Lehrer, Herrn Dr. med. Czeslaw Andrzejewski, zum 70. Geburtstag gewidmet!

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Moskopp, D., Brassel, F. & Ries, F. Intrakranielle und intraspinale Blutungen unter Behandlung mit Cumarinderivaten. Klin Wochenschr 65, 781–790 (1987). https://doi.org/10.1007/BF01743254

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