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Harnsteroidprofile bei Cushing Syndrom und Tumoren der Nebennierenrinde

Urinary steroid profiles in Cushing's syndrome and tumors of the adrenal cortex

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Summary

The analysis of 24-h excretion profiles of urinary steroids in 18 patients suffering from Cushing's syndrome or adrenocortical tumors revealed typical patterns when compared to 37 healthy control persons, 24 patients with obesity, and 6 patients with hirsutism. The validation of eight criteria — increased excretion of free cortisol, 6β-hydroxycortisol, 20α-dihydrocortisol, 11β-hydroxyandrosterone, and 3β-hydroxy-5-en steroids, decreased ratio of tetrahydrocortisone (THE) to tetrahydrocortisol (THF), and increased ratios of THF to allotetrahydrocortisol (a-THF) and metabolites of androgens (AM) to metabolites of cortisol (CM) — afforded reliable detection of disorders in steroid biosynthesis. The analysis of urinary steroid profiles can therefore be recommended as a screening procedure in patients with clinical symptoms of disorders in steroid production and/or metabolism.

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Abbreviations

An:

Androsteron

Aet:

Aetiocholanolon

AM:

Androgenmetaboliten: An plus Aet

11-O-An:

11-Ketoandrosteron

11-OH-An:

11-Hydroxyandrosteron

11-OH-Aet:

11-Hydroxyaetiocholanolon

DHEA:

Dehydroepiandrosteron

16α-OH-DHEA:

16α-Hydroxydehydroepiandrosteron

16β-OH-DHEA:

16β-Hydroxydehydroepiandrosteron

A5T-16α:

Androsten-3β,16α,17β-triol

P5T:

Pregnentriol-3β-hydroxy-5-en Steroide: DHEA plus Androstendiole plus 16α-OH-DHEA plus 16β-OH-DHEA plus

P5D:

Pregnendiol plus A5T-16α plus 16α-Hydroxypregnenolon plus P5T

THE:

Tetrahydrocortison

THF:

Tetrahydrocortisol

a-THF:

Allotetrahydrocortisol

CM:

Cortisolmetaboliten: THE plus THF plus a-THF.

α-C,β-C:

Cortole

α-CL,β-CL:

Cortolone

6β-OH-F:

6β-Hydroxycortisol

20α-OH-F:

20α-Dihydrocortisol

NNR:

Nebennierenrinde

CRF:

Corticotropin Releasing Hormon

ACTH:

Adrenocorticotropes Hormon

CPB:

Competitive Protein Binding

RIA:

Radioimmunoassay

HPLC:

High Pressure Liquid Chromatography

DHEAS:

Dehydroepiandrosteron-Sulfat.

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Authors and Affiliations

  1. Zentrum für Kinderheilkunde, Abteilung I der Universität Ulm/Donau, Germany

    J. Homoki, R. Holl & W. M. Teller

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  1. J. Homoki
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  2. R. Holl
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  3. W. M. Teller
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Mit Unterstützung der Deutschen Forschungsgemeinschaft, Ho-471/5-1

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Homoki, J., Holl, R. & Teller, W.M. Harnsteroidprofile bei Cushing Syndrom und Tumoren der Nebennierenrinde. Klin Wochenschr 65, 719–726 (1987). https://doi.org/10.1007/BF01736807

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  • DOI: https://doi.org/10.1007/BF01736807

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