Summary
In order to study left ventricular function digitized M-mode-echocardiograms were analyzed. 34 patients with insulin-dependent diabetes mellitus (mean age 37.8 years, mean diabetes history 21.5 years) were compared with 35 healthy individuals (mean age 40.9 years). Only patients with negative exercise-ECG, normal 2-D-echocardiogram and normal systemic arterial blood pressure were enclosed.
In diabetics the time-constant Te of free wall endocardial retraction was significantly prolonged (76.8±21.2 ms versus 64.0±7.9 ms in normals, p<0.005), the dimension change during early diastole (dD DS-ERF) was significantly reduced (54.5±13.1% versus 69.8±9% in normals, p<0.001) and the dimension change during atrial contraction phase (dD ACP) was significantly enlarged (23.4±14.4% versus 14.3±6.4% in normals, p<0.001).
These data suggest that impaired left ventricular diastolic function can be found in patients with long standing insulin-dependent diabetes mellitus.
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Abbreviations
- EDD:
-
left ventricular end-diastolic dimension
- ESD:
-
left ventricular end-systolic dimension
- Te:
-
time constant of posterior wall endocardial retraction
- DS:
-
end of systole
- ERF:
-
end of rapid filling
- SFP:
-
slow filling phase
- ACP:
-
atrial contraction phase
- IVS:
-
interventricular septum
- PW:
-
posterior wall
- dD:
-
dimension change
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Park, J.W., Ziegler, A.G., Janka, H.U. et al. Left ventricular relaxation and filling pattern in diabetic heart muscle disease: An echocardiographic study. Klin Wochenschr 66, 773–778 (1988). https://doi.org/10.1007/BF01726577
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DOI: https://doi.org/10.1007/BF01726577