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The influence of nutrition on the systemic availability of drugs

Part II: Drug metabolism and renal excretion

  • Pharmakologika
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References

  1. Abernethy DR, Greenblatt DJ (1982) Pharmacokinetics of drugs in obesity. Clin Pharmacokin 7:108–124

    Google Scholar 

  2. Abernethy DR, Greenblatt DJ (1986) Drug disposition in obese humans. An update. Clin Pharmacokin 11:199–213

    Google Scholar 

  3. Alvarez AP (1978) Interaction between environmental chemicals and drug biotransformation in man. Clin Pharmacokin 3:462–477

    Google Scholar 

  4. Alvarez AP, Anderson KE, Conney AH, Kappas A (1976) Interactions between nutritional factors and drug biotransformation in man. Proc Natl Acad Sci (USA) 73:2501–2504

    Google Scholar 

  5. Alvarez AP, Fischbein A, Anderson KE, Kappas A (1977) Alterations in drug metabolism in workers exposed to polychlorinated biphenyls. Clin Pharmacol Ther 22:140–146

    Google Scholar 

  6. American Diabetes Association: Special Report (1979) Principles of nutrition and dietary recommendations for individuals with diabetes mellitus: 1979. Diabetes 28:1027–1030

    Google Scholar 

  7. American Heart Association Special Report (1984) Recommendations for treatment of hyperlipidemia in adults: A joint statement of the Nutrition Committee and the Council on Arteriosclerosis. Circulation 69:1067A-1090A

    Google Scholar 

  8. Anderson KE, Conney AH, Kappas A (1979) Nutrition and oxidative drug metabolism in man: relative influence of dietary lipids, carbohydrate and protein. Clin Pharmacol Ther 26:493–501

    Google Scholar 

  9. Anderson KE, Schneider J, Pantuck EJ, Pantuck CB, Mudge GH, Welch RM, Conney AH, Kappas A (1983) Acetaminophen metabolism in subjects fed charcoalbroiled beef. Clin Pharmacol Ther 34:369–374

    Google Scholar 

  10. APV — Arbeitsgemeinschaft für pharmazeutische Verfahrenstechnik, Fachgruppe „Biopharmazie“ (1987) Untersuchungen zur Bioverfügbarkeit, Bioäquivalenz. APV — Richtlinie. Pharm Ind 49:704–707

    Google Scholar 

  11. APV — International Association for Pharmaceutical Technology, Working Group “Biopharmacy” (1987) Investigations of bioavailability, bioequivalence. Drugs Made In Germany (in press)

  12. Back DJ, Breckenridge AM, MacIver M, Orme MLE, Purba H, Rowe PH (1981) Interaction of ethinylestradiol with ascorbic acid in man. Br Med J 282:1516

    Google Scholar 

  13. Back DJ, Bates M, Breckenridge AM, Crawford F, Ellis A, Hall JM, MacIver M, Orme MLE, Taylor I, Rowe PH (1981) Drug metabolism by the gastrointestinal mucosa: Clinical aspects. In: Prescott LF, Nimmo WS (eds). Drug absorption. MTP-Press Limited, Lancester, pp 80–86

    Google Scholar 

  14. Back DJ, Breckenridge AM, MacIver M, Orme M, Purba HS, Rowe PH, Taylor I (1982) The gut wall metabolism of ethinyloestradiol and its contribution to the pre-systemic metabolism of ethinyloestradiol in humans. Br J clin Pharmacol 13:325–330

    Google Scholar 

  15. Balabaud C, Vinon G, Paccalin J (1979) Influence of dietary protein and carbohydrate on phenytoin metabolism in man. Br J clin Pharmacol 8:369–371

    Google Scholar 

  16. Barsotti G, Ciardella F, Gretz N, Giovanetti S (1986) Protection of residual renal function in chronic uremia by dietary therapy: Clinical and experimental observations. Akt Ernähr 11:61–65

    Google Scholar 

  17. Baylis EM, Crowley JM, Preece JM, Sylvester PE, Marks V (1971) Influence of folic acid on blood phenytoin levels. Lancet I:62–64

    Google Scholar 

  18. Bennion M (1979) Clinical Nutrition. Harper & Row Publishers, New York

    Google Scholar 

  19. Berlinger WG, Park GD, Spector R (1985) The effect of dietary protein on the clearance of allopurinol and oxipurinol. N Engl J Med 313:771–776

    Google Scholar 

  20. Bianchine JR, Shaw GM (1976) Clinical pharmacokinetics of levodopa in parkinson's disease. Clin Pharmacokin 1:313–338

    Google Scholar 

  21. Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S (1983) Renal function reserve in humans: effect of protein intake on glomerular filtration rate. Am J Med 75:943–950

    Google Scholar 

  22. Brenner BM, Meyer TW, Hostetter TH (1982) Dietary protein intake and the progressive nature of kidney disease. N Engl J Med 307:652–659

    Google Scholar 

  23. Briggs MH (1981) Megadose vitamin C and metabolic effects of the pill. Br med J 283:1547

    Google Scholar 

  24. Brodie KJ, Boobis AR, Toverud EL (1980) Drug metabolism in white vegetarians. Br J clin Pharmacol 9:523–525

    Google Scholar 

  25. Bucht H, Ahlberg M, Alvestrand A, Gutierrez A, Bergström J (1986) The effect of low protein diet on the progression of renal failure in man. In Bertani T, Remuzzi G, Garattini S (eds) Drugs and kidney. Raven Press, New York, pp 257–267

    Google Scholar 

  26. Burgess P, Hall RI, Bateman DN, Johnston IDA (1985) Antipyrine clearance during total parenteral nutrition in man. Br J clin Pharmacol 20:253P-254P

    Google Scholar 

  27. Byrne AJ, McNeil JJ, Harrison PM, Louis W, Tonkin AM, McLean AJ (1984) Stable oral availability of sustained release propranolol when co-administered with hydralazine or food: evidence implicating substrate delivery rate as a determinant of presystemic drug interactions. Br J clin Pharmacol 17:45S-50S

    Google Scholar 

  28. Camien MN, Reilly TJ (1967) Determination of titrable ash-acidity (ash-TA). Proc Soc Exp Biol Med 126:51–55

    Google Scholar 

  29. Challenor VF, Waller DG, Gruchy BS, Renwick AG, George CF (1987) Food and nifedipine kinetics. Br J clin Pharmacol 23:248–249

    Google Scholar 

  30. Connelly JC, Bridges JW (1980) Teh distribution and role of cytochrome P-450 in extrahepatic organs. In: Bridges JW, Chasseaud LF (eds) Progress in drug metabolism. Vol 5. John Wiley & Sons, Chichester, pp 1–111

    Google Scholar 

  31. Conney AH, Pantuck EJ, Hsiao KC, Garland WA, Anderson KE, Alvarez AP, Kappas A (1976) Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin Pharmacol Ther 20:633–642

    Google Scholar 

  32. Conney AH, Pantuck EJ, Kuntzman R, Kappas A, Anderson KE, Alvarez AP (1977) Nutrition and chemical biotransformation in man. Clin Pharmacol Ther 22:707–719

    Google Scholar 

  33. Conney AH, Pantuck EJ, Hsiao KC, Kuntzman R, Alvarez AP, Kappas A (1977) Regulation of drug metabolism in man by environmental chemicals and diet. Fed Proc 36:1647–1652

    Google Scholar 

  34. Daneshmend TK, Roberts CJC (1982) The influence of food on the roal and the intravenous pharmacokinetics of a high clearance drug: A study with labetalol. Br J clin Pharmacol 14:73–78

    Google Scholar 

  35. Daneshmend TK, Jackson L, Roberts CJC (1981) Physiological and pharmacological variability in estimated bepatic blood flow in man. Br J clin Pharmacol 11:491–496

    Google Scholar 

  36. Davies DS, Ilett KF, George CF (1981) Drug metabolism by intestinal mucosa. In: Prescott LF, Nimmo WS (eds) Drug Absorption. MTP-Press Limited, Lancaster, pp 73–79

    Google Scholar 

  37. Dennis MJ, Massey RC, McWeeny DJ, Knowles ME (1983) Analysis of polycyclic aromatic hydrocarbons in UK total diets. Fd Chem Toxic 21:569–574

    Google Scholar 

  38. Deutsche Gesellschaft für Ernährung (1985) Empfehlungen für die Nährstoffzufuhr. 4. erweiterte Überarbeitung. Umschau-Verlag, Frankfurt/Main

    Google Scholar 

  39. Dickson CJ, Schwartzman MS, Bertino JS Jr (1986) Factors affecting aminoglycoside disposition: Effects of circadian rhythm and dietary protein intake on gentamycin pharmacokinetics. Clin Pharmacol Ther 39:325–328

    Google Scholar 

  40. Donn KH, Powell JR, Rodgers JF, Plachetka JR (1984) Lack of effect of histamine H2-receptor antagonists on indocyanine green disposition measured by two methods. J clin Pharmacol 24:360–370

    Google Scholar 

  41. Døssing M (1982) Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals. Clin Pharmacol Ther 32:340–346

    Google Scholar 

  42. Drouillard DD, Vesell ES, Dvorchik BH (1978) Studies on theobromine disposition in normal subjects. Alterations induced by dietary abstention from or exposure to methylxanthines. Clin Pharmacol Ther 23:296–302

    Google Scholar 

  43. Dunne JW, Davidson L, Vandongen R, Beilin LJ, Tunney AM, Rodgers PB (1984) The effect of ascorbic acid on the sulfate conjugation of ingested noradrenanline and dopamine. Br J clin Pharmacol 17:356–360

    Google Scholar 

  44. Duvoisin RC, Yahr MD, Coté LD (1969) Pyridoxine reversal of L-DOPA effects in parkinsonism. Trans Am Neurol Ass 94:81–84

    Google Scholar 

  45. Eichelbaum M, Somogyi A (1984) Inter- and intra-subject variation in the first-pass elimination of highly cleared drugs during chronic dosing. Eur J clin Pharmacol 26:47–53

    Google Scholar 

  46. Ekstrand J, Spak CJ, Ehrnebo M (1982) Renal clearance of fluoride in a steady state condition in man: Influence of urinary flow and pH changes by diet. Acta Pharmacol Toxicol 50:321–325

    Google Scholar 

  47. Elion GB (1978) Allopurinol and other inhibitors of urate synthesis. In: Kelley WN, Weiner JM (eds) Handb Exp Pharmacol Vol 51, Uric Acid. Springer Verlag, Berlin, pp 485–514

    Google Scholar 

  48. Elvin AT, Cole AFD, Pieper JA, Rolbin SH, Lalka D (1981) Effect of food on lidocaine kinetics: Mechanism of food-related alteration in high intrinsic clearance drug elimination. Clin Pharmacol Ther 30:455–460

    Google Scholar 

  49. European Atherosclerosis Society, Study Group (1987) Strategies for the prevention of coronary heart disease: A policy statement of the European Atherosclerosis Society. Eur Heart J 8:77–88

    Google Scholar 

  50. Fagan TC, Walle T, Oexmann MJ, Walle UK, Bai SA, Gaffney TE (1987) Increased clearance of propranolol and theophylline by high-protein compared with high-carbohydrate diet. Clin Pharmacol Ther 41:402–406

    Google Scholar 

  51. Feely J, Nadeau J, Wood AJJ (1983) Effects of feeding on the systemic clearance of indocyanine green and propranolol blood concentrations and plasma binding. Br J clin Pharmacol 15:383–385

    Google Scholar 

  52. Feldman CH, Hutchinson VE, Pippenger CE, Blumenfeld TA, Feldman BR, Davis WJ (1980) Effect of dietary protein and carbohydrate on theophylline metabolism in children. Pediatrics 66:956–962

    Google Scholar 

  53. Fraser HS, Mucklow JC, Bulpitt CJ, Khan C, Mould G, Dollery CT (1977) Environmental effects on antipyrine half life in man. Clin Pharmacol Ther 22:799–805

    Google Scholar 

  54. Furlanut M, Benetello P, Avogaro A, Dainese R (1978) Effects of folic acid on phenytoin kinetics in healthy subjects. Clin Pharmacol Ther 24:295–297

    Google Scholar 

  55. George CF (1981) Drug metabolism by the gastrointestinal mucosa. Clin Pharmacokin 6:259–274

    Google Scholar 

  56. Goldin BR, Swenson L, Dwyer J, Sexton M, Gorbac SL (1980) Effect of diet and lactobacillus acidophilus supplements on human fecal bacterial enzymes. J Natl Cancer Inst 64:255–262

    Google Scholar 

  57. Grimmer G, Hildebrandt A (1965) Kohlenwasserstoffe in der Umgebung des Menschen. II. Mitteilung. Der Gehalt polycyclischer Kohlenwasserstoffe in Brotgetreide verschiedener Standorte. Z Krebsforsch 67:272–277

    Google Scholar 

  58. Hansson O, Sillanpaa M (1976) Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet I:256

    Google Scholar 

  59. Hasslacher CH, Borgholte G, Geiss R, Wahl P, Ritz E (1986) Einfluß einer eiweißreduzierten Diät auf den Verlauf der klinisch manifesten diabetischen Nephropathie. Akt Endokrin Stoffw 7:81

    Google Scholar 

  60. Herz R, Rössle M, Bonzel T, Keller E, Gerok W (1984) Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver. Klin Wochenschr 62:759–764

    Google Scholar 

  61. Hill MJ (1982) Colonic bacterial activity. Effect of fiber on substrate concentration and on enzyme action. In: Vahouny GV, Kritchevsky D (eds) Dietary fiber in health and disease. Plenum Press, New York London, pp 35–43

    Google Scholar 

  62. Hoensch HP, Hutt R, Hartmann F (1979) Eigenschaften des mikrosomalen fremdstoffabbauenden Enzymsystems im Dünndarm des Menschen. Z Gastroenterologie 17:600

    Google Scholar 

  63. Hoensch HP, Steinhardt HJ, Weiss G, Haug D, Maier A, Malchow H (1984) Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosa in humans. Gastroenterology 86:1519–1530

    Google Scholar 

  64. Houston JB (1977) Effect of vitamin C supplement on antipyrine disposition in man. Br J clin Pharmacol 4:236–239

    Google Scholar 

  65. Houston JB, Levy G (1975) Modification of drug biotransformation by vitamin C in man. Nature (London) 255:78–79

    Google Scholar 

  66. Hsu TH, Bianchine JR, Preziosi TJ, Messiha FS (1973) Effect of pyridoxine on levodopa metabolism in normal and parkinsonian patients. Proc Soc exp Biol (N.Y.) 143:578–581

    Google Scholar 

  67. Hunt SM, Groff JL, Holbrook JM (1980) Nutrition: Principles and Clinical Practice. John Wiley & Sons Inc, New York

    Google Scholar 

  68. Jacobs LR (1986) Dietary fiber and gastrointestinal epithelial cell proliferation. In: Vahouny GV, Kritchevsky D (eds) Dietary fiber. Basic and clinical aspects. Plenum Press. New York, pp 211–228

    Google Scholar 

  69. Juan D, Worwag EM, Schoeller DA, Kotake AN, Hughes RL, Frederiksen MC (1986) Effects of dietary protein on theophylline pharmacokinetics and caffeine and aminopyrine breath tests. Clin Pharmacol Ther 40:187–194

    Google Scholar 

  70. Kahn HD, Panariello VA, Saeli J, Sampson JR, Schwartz E (1967) Effect of cranberry juice on urine. J Am Diet Ass 51:251–254

    Google Scholar 

  71. Kaminsky LS, Dunbar DA, Wang PP, Beaune P, Larrey D, Guengerich FP, Schnellmann RG, Sipes IG (1984) Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. Drug Metab Disposition 12:470–477

    Google Scholar 

  72. Kapitulnik J, Poppers PJ, Buenig MK, Fortner JG, Conney AH (1977) Activation of monooxygenases in human liver by 7,8-benzoflavone. Clin Pharmacol Ther 22:475–484

    Google Scholar 

  73. Kappas A, Anderson KE, Conney AH, Alvarez AP (1976) Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in man. Clin Pharmacol Ther 20:643–653

    Google Scholar 

  74. Kappas A, Alvarez AP, Anderson KE, Pantuck EJ, Pantuck CB, Chang R, Conney AH (1978) Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clin Pharmacol Ther 23:445–450

    Google Scholar 

  75. Kempin SJ (1983) Warfarin resistance caused by broccoli. N Engl J Med 308:1229–1230

    Google Scholar 

  76. Klingeberg J (1972) Die Beeinflussung der aktuellen Harnreaktion durch verschiedene Getränke im Rahmen der Harnsteintherapie und -prophylaxe. Urologe (Ausgabe B) 12:155–157

    Google Scholar 

  77. Klotz U, Reimann I (1983) Einfluß von Histamin H2-Rezeptorantagonisten auf die hepatische Elimination von Arzneimitteln. Klin Wochenschr 61:625–632

    Google Scholar 

  78. Krishnaswamy K (1978) Drug metabolism and pharmacokinetics in malnutrition. Clin Pharmacokin 3:216–240

    Google Scholar 

  79. Krishnaswamy K, Kalamegham R, Naidu NA (1984) Dietary influences on the kinetics of antipyrine and aminopyrine in human subjects. Br J clin Pharmacol 17:139–146

    Google Scholar 

  80. Kutz K, Deres M, Schnarr S, Schiermayer B, Haberland D (1982) Effect of cimetidine on the transport of organic anions. Z Gastroenterologie 20:573–574

    Google Scholar 

  81. LaDu B (1977) Effects of GRAS substances on pharmacologic effects of drugs. Clin Pharmacol Ther 22:743–747

    Google Scholar 

  82. Lane EA, Guthrie S, Linnoila M (1985) Effects of ethanol on drug and metabolite pharmacokinetics. Clin Pharmacokin 10:228–247

    Google Scholar 

  83. Langendorf H (1963) Säuren-Basen-Gleichgewicht und chronische acidogene und alkalogene Ernährung. Z Ernährungsw (Suppl 2):1–72

    Google Scholar 

  84. Larsson BK (1982) Polycyclic aromatic hydrocarbons in smoked fish. Z Lebensm Unters Forsch 174:101–107

    Google Scholar 

  85. Liedholm H, Melander A (1986) Concomitant food intake can increase the bioavailability of propranolol by transient inhibition of its presystemic primary conjugation. Clin Pharmacol Ther 40:29–36

    Google Scholar 

  86. Liedholm H, Wahlin-Boll E, Hanson A, Melander A (1982) Influence of food on the bioavailability of “real” and “apparent” hydralazine from conventional and slow-release preparations. Drug-Nutrient Interactions 1:293–302

    Google Scholar 

  87. Ludden TM, McNay JL Jr, Shepherd AMM, Lin MS (1982) Clinical pharmacokinetics of hydralazine. Clin Pharmacokin 7:185–205

    Google Scholar 

  88. Maxwell JD, Hunter J, Stewart DA, Ardeman S, Williams R (1972) Folate deficiency after anticonvulsant drugs. An effect of hepatic enzyme induction. Br Med J 1:297–299

    Google Scholar 

  89. McLean AJ, Isbister C, Bobik A, Dudley FJ (1981) Reduction of first pass hepatic clearance of propranolol by food. Clin Pharmacol Ther 30:31–34

    Google Scholar 

  90. Melander A (1978) Influence of food on the bioavailability of drugs. Clin Pharmacokin 3:337–351

    Google Scholar 

  91. Melander A, McLean A (1983) Influence of food intake on presystemic clearance of drugs. Clin Pharmacokin 8:286–296

    Google Scholar 

  92. Melander A, Danielson K, Hanson A, Rudell B, Scherstén B, Thulin T, Wahlin E (1977) Enhancement of hydralazine bioavailability by food. Clin Pharmacol Ther 22:104–107

    Google Scholar 

  93. Melander A, Danielson K, Scherstén B, Wahlin E (1977) Enhancement of the bioavailability of propranolol and metoprolol by food. Clin Pharmacol Ther 22:108–112

    Google Scholar 

  94. Melander A, Liedholm H, McLean A (1985) Concomitant food intake does enhance the bioavailability and the effect of hydralazine. Clin Pharmacol Ther 38:475

    Google Scholar 

  95. Monks TJ, Caldwell J, Smith RL (1979) Influence of methylxanthine-containing foods on theophylline metabolism and kinetics. Clin Pharmacol Ther 26:513–524

    Google Scholar 

  96. Mucklow JC, Caraher MT, Henderson DB, Rawlins MD (1979) The effect of individual dietary constituents on antipyrine clearance in Asian immigrants. Br J clin Pharmacol 7:416P-417P

    Google Scholar 

  97. Mucklow JC, Caraher MT, Idle JR, Rawlins MD, Sloan T, Smith RL, Wood P (1980) The influence of changes in dietary fat on the clearance of antipyrine and 4-hydroxylation of debrisoquine. Br J clin Pharmacol 9:283P

  98. Mucklow JC, Rawlins MD, Brodie MJ, Boobis AR, Dollery CT (1980) Drug oxidation in Asian vegetarians. Lancet II:151

    Google Scholar 

  99. Nedden R, Fuchs T, Schröder K, Wundt W (1972) Die renale Ausscheidung von Gentamycin beim Menschen. Dtsch med Wochenschr 97:1496–1503

    Google Scholar 

  100. Nestle M (1985) Nutrition in clinical practice. Jones Medical Publications, Grenbrae

    Google Scholar 

  101. Neuvonen PJ, Kärkkäinen S (1983) Effect of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics. Clin Pharmacol Ther 33:386–393

    Google Scholar 

  102. Neuvonen PJ, Kärkkäinen S, Lehtovaara R (1987) Pharmacokinetics of chlorpropamide in epileptic patients: Effects of enzyme induction and urine pH on chlorpropamide elimination. Eur J Clin Pharmacol 32:297–301

    Google Scholar 

  103. Ogilvie RI (1976) Clinical pharmacokinetics of theophylline. Clin Pharmacokin 3:267–273

    Google Scholar 

  104. Olanoff LS, Walle T, Cowart TD, Walle UK, Oexmann MJ, Conradi EC (1986) Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesis. Clin Pharmacol Ther 40:408–414

    Google Scholar 

  105. Onrot J, Shaheen O, Biaggioni I, Goldberg MR, Feely J, Wilkinson GR, Hollister AS, Robertson D (1986) Reduction of liver plasma flow by caffeine and theophylline. Clin Pharmacol Ther 40:506–510

    Google Scholar 

  106. Orme ML'E, Back DJ, Breckenridge AM (1983) Clinical pharmacokinetics of oral contraceptive steroids. Clin Pharmacokin 8:95–136

    Google Scholar 

  107. Overdiek HWPM, Merkus FWHM (1986) Influence of food on the bioavailability of spironolactone. Clin Pharmacol Ther 40:531–536

    Google Scholar 

  108. Padova J, Bendersky G (1962) Hyperuricemia in diabetic ketoacidosis. N Engl J Med 267:530–534

    Google Scholar 

  109. Pantuck EJ, Hsiao KC, Conney AH, Garland WA, Kappas A, Anderson KE, Alvarez AP (1976) Effect of charcoal-broiled beef on phenacetin metabolism in man. Science 194:1055–1057

    Google Scholar 

  110. Pantuck EJ, Pantuck CB, Garland WA, Mins BH, Wattenberg LW, Anderson KE, Kappas A, Conney AH (1979) Stimulatory effect of Brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol Ther 25:88–95

    Google Scholar 

  111. Pantuck EJ, Pantuck CB, Anderson KE, Wattenberg LW, Conney AH, Kappas A (1984) Effect of Brussels sprouts and cabbage on drug conjugation. Clin Pharmacol Ther 35:161–169

    Google Scholar 

  112. Park GD, Berlinger WG, Spector R, Kitt TM, Tsalikian E (1987) Sustained reductions in oxipurinol renal clearance during a restricted diet. Clin Pharmacol Ther 41:616–621

    Google Scholar 

  113. Peppercorn MA (1984) Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development. Ann Intern Med 101:377–386

    Google Scholar 

  114. Powell JR, Donn KH (1984) Histamine H2-antagonist drug interactions in perspective: Mechanistic concepts and clinical implications. Am J Med 77 (Suppl 5B):57–84

    Google Scholar 

  115. Prescott LP (1973) Clinically important drug interactions. Drugs 5:161–186

    Google Scholar 

  116. Qureshi GD, Reinders TP, Swint JJ, Slate MB (1981) Aquired warfarin resistance and weight-reducing diet. Arch Intern Med 141:507–509

    Google Scholar 

  117. Reddy BS, Weisburger JH, Wynder EL (1974) Fecal bacterial β-glucuronidase: Control by diet. Science 183:416–417

    Google Scholar 

  118. Reiter S, Löffler W, Gröbner W, Zöllner N (1984) Influence of dietary purines on the metabolism of allopurinol in man. Wld Rev Nutr Diet 43:187–191

    Google Scholar 

  119. Richardson PDI, Wirthington PG (1981) Liver blood flow I: Intrinsic and nervous control of liver blood flow. Gastroenterology 81:159–173

    Google Scholar 

  120. Richardson PDI, Wirthington PG (1981) Liver blood flow II: Effects of drugs and hormons on liver blood flow. Gastroenterology 81:356–375

    Google Scholar 

  121. Routledge PA, Shand DG (1979) Clinical pharmacokinetics of propranolol. Clin Pharmacokin 4:73–90

    Google Scholar 

  122. Rowland IR, Mallett AK, Wise A (1983) A comparison of the activity of five microbial enzymes in cecal content from rats, mice and hamsters, and response to dietary pectin. Toxicol Appl Pharmacol 69:143–148

    Google Scholar 

  123. Rowland IR, Wise A, Mallett AK (1983) Metabolic profile of caecal micro-organisms from rats fed indigestible plant cell-wall components. Fd Chem Toxic 21:25–29

    Google Scholar 

  124. Santodonato J, Howard P, Dasu D (1981) Health and ecological assessment of polynuclear aromatic hydrocarbons. J Environ Pathol Toxicol 5:1–364

    Google Scholar 

  125. Schneck DW, Vary JE (1984) Mechanism by which hydralazine increases propranolol bioavailability. Clin Pharmacol Ther 35:447–453

    Google Scholar 

  126. Sellers EM, Hollway MR (1978) Drug kinetics and alcohol ingestion. Clin Pharmacokin 3:440–452

    Google Scholar 

  127. Shepherd AMM, McNay JL, Ludden TM, Lin MS, Musgrave GE (1981) Plasma concentration and acetylator phenotype determine response to oral hydralazine. Hypertension 3:580–585

    Google Scholar 

  128. Shepherd AMM, Irvine NA, Ludden TM (1984) Effect of food on hydralazine levels and response in hypertension. Clin Pharmacol Ther 36:14–18

    Google Scholar 

  129. Smits P, Pieters G, Thien T (1986) The role of epinephrine in the circulatory effects of coffee. Clin Pharmacol Ther 40:431–437

    Google Scholar 

  130. Souci SW, Fachmann W, Kraut H (1986) Food composition and nutrition tables 1986/87. 3rd revised and completed edition. Dtsch Forschungsanstalt für Lebensmittelchemie (ed). Revised by Scherz H, Kloos G, Senser F. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  131. Svensson CK, Edwards DJ, Muriello PM, Barde SH, Foster AC, Lanc RA, Middleton E Jr, Lalka D (1983) Effect of food on hepatic blood flow: Implications in the “food effect” phenomenon. Clin Pharmacol Ther 34:316–323

    Google Scholar 

  132. Svensson CK, Muriello PM, Barde SH, Middleton E, Lalka D (1984) Effect of carbohydrates on estimated hepatic blood flow. Clin Pharmacol Ther 35:660–665

    Google Scholar 

  133. Svensson CK, Cumella JC, Tronolone M, Middleton E Jr, Lalka D (1985) Effects of hydralazine, nitroglycerin, and food on estimated hepatic blood flow. Clin Pharmacol Ther 37:464–468

    Google Scholar 

  134. Tranvouez JL, Lerebours E, Chretien P, Fouin-Fortunet H, Colin R (1985) Hepatic antipyrine metabolism in malnourished patients: Influence of the type of malnutrition and course after nutritional rehabilitation. Am J clin Nutr 41:1257–1264

    Google Scholar 

  135. Walker FB (1984) Myocardial infarction after diet-induced warfarin resistance. Arch Intern Med 144:2089–2090

    Google Scholar 

  136. Walle T, Fagant TC, Walle K, Oexmann MJ, Conradi EC, Gaffney TE (1981) Food-induced increase in propranolol bioavailability — relationship to protein and effects on metabolites. Clin Pharmacol Ther 30:790–795

    Google Scholar 

  137. Walter-Sack I (1985) Einflüsse der Ernährung auf den Abbau und die renale Ausscheidung von Arzneimitteln beim Menschen. Dtsch Ärztebl 82:2883–2887

    Google Scholar 

  138. Walter-Sack I (1986) Ernährung und Arzneimittel — Aktuelle Probleme. Verh Dtsch Ges Inn Med 92:270–277

    Google Scholar 

  139. Walter-Sack I (1987) Empfehlungen für die Berücksichtigung von Ernährungseinflüssen bei der Prüfung der systemischen Verfügbarkeit von Arzneimitteln. In: Bioavailability/Bioequivalence, Pharmaceutical and Therapeutic Equivalence (Abstracts). International Symposium of the APV — Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik — International Association for Pharmaceutical Technology. Würzburg, February 9–11, 1987

  140. Walter-Sack I (1987) The influence of nutrition on the systemic availability of drugs. Part I: Drug absorption. Klin Wochenschr 65:927–935

    Google Scholar 

  141. Walter-Sack I, Gröbner W, Zöllner N (1979) Verlauf der Oxipurinol-Spiegel im Plasma nach akuter und chronischer Gabe von Allopurinol in verschiedenen galenischen Zubereitungen. Arzneim.-Forsch/Drug Res 29:839–842

    Google Scholar 

  142. Wattenberg LW (1980) Inhibitors of chemical carcinogens. J Environ Pathol Toxicol 3:35–52

    Google Scholar 

  143. Wattenberg LW, Loub WD (1978) Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally-occurring indoles. Cancer Res 38:1410–1413

    Google Scholar 

  144. Weiner IM, Blanchard KC, Mudge GH (1964) Factors influencing renal excretion of foreign organic acids. Am J Physiol 207:953–963

    Google Scholar 

  145. Winter J, O'Rourke-Locascio S, Bokkenheuser VD, Mosbach EH, Cohen BI (1984) Reduction of 17-keto steroids by anaerobic microorganisms isolated from human fecal flora. Biochim Biophys Acta 795:208–211

    Google Scholar 

  146. Wise A, Gilburt DJ (1982) Dietary influence on caecal microbial nitroreduction of a drug: metronidazole. Drug-Nutrient Interactions 1:229–236

    Google Scholar 

  147. Woodcock BG, Kraemer N, Rietbrock N (1986) Effect of a high protein meal on the bioavailability of verapamil. Br J clin Pharmacol 21:337–338

    Google Scholar 

  148. Zöllner N (1978) Feststellung des Ernährungszustandes. In: Kühn HA, Zöllner N (eds) Allgemeine und klinische Ernährungslehre. Bd II, Teil I. Georg Thieme Verlag Stuttgart, pp 1–7

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  1. Abteilung Klinische Pharmakologie, Medizinische Klinik, Universität Heidelberg, Germany

    I. Walter-Sack

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  1. I. Walter-Sack
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The manuscript is part of a lecture at the APV-Symposium on Bioavailability/Bioequivalence, Pharmaceutical and Therapeutic Equivalence. Würzburg, February 9–11, 1987

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Walter-Sack, I. The influence of nutrition on the systemic availability of drugs. Klin Wochenschr 65, 1062–1072 (1987). https://doi.org/10.1007/BF01726326

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