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Early metabolic treatment after liver transplant: Amino acid tolerance

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Abstract

Objective

We investigated the amino acid (AA) tolerance during Total Parenteral Nutrition (TPN) in adult patients undergone liver transplant (LTX).

Design

The treatment (Glucose and AA), induced on the 2nd postoperative day, was later maintained with 27 kcal/kg Ideal Body Weight (IBW) as glucose and 0.12 (12 patients: protocol #1), 0.18 (10 patients: protocol #2) and 0.25 g nitrogen (N)/kg IBW (13 patients: protocol #3) till end of the 6th postoperative day. The N intake was sequentially modified in protocol #2 and #3 to increase the supply of the amino acid (AA) that resulted in an infusion plasma level below the expected “normal” range (between 1 and 1.6 times the overnight fasting plasma level of volunteer).

Patients

35 consecutive adult patients without diabetes and organ failures for the entire study period.Measurements: Plasma AA profile was measured before LTX and at the last TPN day under continuous infusion. During #1 and #2 protocol, many AA resulted below or at the lower range of the norm while, during 0.25 gN/kg IBW infusion, the majority of the administered AA significantly increased with respect to reference values. Nevertheless, they remained in the “normal” plasma range indicating that they were supplied in an optimal amount (particularly the aromatic and sulphurated ones, potentially toxic if liver function is impaired, and the branched chain AA (BCAA) given at consistent dosage: 0.5 g/kg). Arginine resulted significantly increased (Arg: 1.9 times the reference) and cystine (Cys: 0.45), serine (Ser: 0.8) and taurine (Tau: 0.85) remained significantly lower than “normal” as well as the not administered citrulline (Cit: 0.58) and alfa amino butyric acid (Aba: 0.41). The AA (and calorie) load almost balanced the N losses during the 5th (0.411±0.038) and 6th study day (0.305±0.019 gN/kg).

Conclusions

0.25 gN/kg could be considered the minimum N load in the uncomplicated adult LTX recipients, for reassuring a balanced plasma AA pattern and body N turnover in the early postoperative phase.

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Authors and Affiliations

  1. ICU “E. Vecla”, Istituto Anestesiologia e Rianimazione dell'Università, IRCCS Ospedale Maggiore, Via F. Sforza 33, I-20122, Milano, Italy

    G. Iapichino, D. Radrizzani, D. Codazzi, A. Colombo, M. Langer, G. Ronzoni & M. Savioli

  2. Centro Trapianto di Fegato, IRCCS Ospedale Maggiore, Via F. Sforza 33, I-20122, Milano, Italy

    B. Gridelli

  3. Servizio de Ricerche Cliniche, Ospedale Regina Margherita, I-10126, Torino, Italy

    G. Bonetti

Authors
  1. G. Iapichino
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  2. D. Radrizzani
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  3. G. Bonetti
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  4. D. Codazzi
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  5. A. Colombo
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  6. B. Gridelli
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  7. M. Langer
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  8. G. Ronzoni
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  9. M. Savioli
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Iapichino, G., Radrizzani, D., Bonetti, G. et al. Early metabolic treatment after liver transplant: Amino acid tolerance. Intensive Care Med 21, 802–807 (1995). https://doi.org/10.1007/BF01700962

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  • DOI: https://doi.org/10.1007/BF01700962

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