Summary
The percentage of activated, CD3+ DR+ and CD8+Leu7+ lymphocytes and the serum neopterin concentration were determined in 17 HIV-seropositive and 10 HIV-seronegative haemophiliacs and in 11 healthy control subjects. All three parameters tested were found to be significantly higher in the seropositive patients than in the seronegative controls. In the seropositive group, a significant positive correlation was found between the neopterin levels and the percentage of CD3+DR+ cells. By contrast, no significant negative or positive correlation was observed between the neopterin levels and the percentage of the CD8+Leu7+ subset. These data suggest that in the HIV-infected patients the activated T cells responsible for the stimulation of macrophages to produce neopterin are those that do not carry CD8.
Similar content being viewed by others
Abbreviations
- CD:
-
cluster designation
- AIDS:
-
acquired immune deficiency syndrome
- HIV:
-
human immunodeficiency virus
- CDC:
-
Centers for Disease Control
References
Ascher MS, Sheppard HW (1990) AIDS as immune system activation II. The panergic imnesia hypothesis. J Acquir Immune Defic Syndr 3:177–191
Bogner JR, Matuschke A, Heinrich B, Eberle E, Goebel F-D (1988) Serum neopterin levels as predictor of AIDS. Klin Wochenschr 66:1015–1018
Bogner JR, Matuschke A, Heinrich B, Schreiber MA, Nerl C, Goebel F-D (1990) Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection. Klin Wochenschr 68:393–396
Fuchs D, Hausen A, Reibnegger G, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H (1989) Interferongamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1. J Acquir Immune Defic Syndr 2:158–162
Kornfeld H, Cruickshank WW, Pyle SW, Berman JS, Center DM (1988) Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335:445–448
Kramer A, Wiktor SZ, Fuchs D, Milstein S, Gail MH, Yellin FJ, Biggar RJ, Wachter H, Kaufman S, Blattner WA, Goedert JJ (1989) Neopterin: A predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection. J Acquir Immune Defic Syndr 2:291–296
Margolick JB, Volkman DJ, Folks TM, Fauci AS (1987) Amplification of HTLVIII/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses. J Immunol 138:1719–1723
Moss AR, Bacchetti P (1989) Natural history of HIV infection. AIDS 3:55–61
Price HE, Kleinman S, Czaplicki C, John J, Williams AE (1990) Interrelationships between serological markers of immune activation and T lymphocyte subsets in HIV infection. J Acquir Immune Defic Syndr 3:525–530
Reibnegger G, Fuchs D, Goedert JJ, Hausen A, Kramer A, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H (1990) Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Klin Wochenschr 68:43–48
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pálóczi, K., Ujhelyi, E., Fuchs, D. et al. Correlation of the percentage of activated, CD3+DR+ lymphocytes to serum neopterin level in HIV-seropositive haemophiliacs. Klin Wochenschr 69, 143–145 (1991). https://doi.org/10.1007/BF01665853
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01665853