Summary
Co-trimoxazole, co-trimazine and sulphalene were tested in a controlled clinical trial of the treatment of urinary tract infections. Forty-three patients were treated with co-trimoxazole, 41 with co-trimazine, and 21 with sulphalene. During the study, sulphalene was found to be inferior to the other drugs and was excluded from further trials. The clinical efficacy of co-trimoxazole and co-trimazine was equal although the doses of trimethoprim and sulphonamide in co-trimoxazole were much higher than that in co-trimazine. In the latter sulphadiazine was used instead of sulphamethoxazole, the intention being to increase the concentration of active sulphonamide in the urine. Side effects tended to be less frequent in the patients treated with co-trimazine, although not significantly.
Zusammenfassung
Co-trimoxazol, Co-trimazin und Sulphalen wurden in einer kontrollierten klinischen Studie über die Behandlung von Harnwegsinfektionen geprüft. Dreiundvierzig Patienten wurden mit Co-trimoxazol, 41 mit Co-trimazin und 21 mit Sulphalen behandelt. Im Verlauf der Studie zeigte sich, daß Sulphalen den anderen Substanzen unterlegen war, und es wurde von weiteren Untersuchungen ausgeschlossen. Die klinische Wirksamkeit von Co-trimoxazol und Co-trimazin war gleich, obwohl die Dosen von Trimethoprim und Sulfonamid in Co-trimoxazol viel höher waren als in Co-trimazin. Bei letzterem wurde Sulphadiazin an Stelle von Sulphamethoxazol verwendet, wobei beabsichtigt war, die Konzentration von aktivem Sulfonamid im Urin zu erhöhen. Es zeigte sich die Tendenz zu weniger häufigen Nebenwirkungen bei Patienten, die mit Co-trimazin behandelt wurden, der Unterschied war jedoch nicht signifikant.
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Lövestad, A., Gästrin, B. & Lundström, R. A clinical study of co-trimazine in comparison with co-trimoxazole and sulphalene in urinary tract infections. Infection 7 (Suppl 4), S401–S403 (1979). https://doi.org/10.1007/BF01639021
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DOI: https://doi.org/10.1007/BF01639021