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Granulomatous reaction and tissue remodelling in the cutaneous lesion of chromomycosis

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Abstract

The cell-mediated immune reaction was studied in the cutaneous lesion of chromomycosis, using monoclonal antibodies against polymorphonuclear neutrophils, macrophage and lymphocyte subsets, endothelial and fibroblast cells. In addition, immunostaining of the main degradative enzymes (neutrophil elastase and interstitial collagenase) and certain important cytokines (transforming growth factor-β, tumour necrosis factor-α and interferon-γ) suggested an explanation for the granulomatous reaction and the associated tissue remodelling. The distribution pattern of neutrophils and macrophage subsets, observed by computer-aided image analysis, suggests that the in situ persistence of fungi is the main pathological factor.

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Authors and Affiliations

  1. Laboratoire de Parasitologie, Institut Pasteur de Guyane and Département de Dermatologie, Hopital Jean Martial, Cayenne, French Guiana

    D. Sainte-Marie & R. Pradinaud

  2. Unité de Physiopathologie des Fibroses Tissulaires/CNRS URA 1459, Institut Pasteur de Lyon, Avenue Tony Garnier, F-69365, Lyon Cédex O7, France

    P. Esterre, S. Peyrol & J. A. Grimaud

Authors
  1. P. Esterre
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  2. S. Peyrol
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  3. D. Sainte-Marie
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  4. R. Pradinaud
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  5. J. A. Grimaud
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Esterre, P., Peyrol, S., Sainte-Marie, D. et al. Granulomatous reaction and tissue remodelling in the cutaneous lesion of chromomycosis. Vichows Archiv A Pathol Anat 422, 285–291 (1993). https://doi.org/10.1007/BF01608337

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  • DOI: https://doi.org/10.1007/BF01608337

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