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Enhancement of anti-tumour effect by cooling

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Abstract

Protamine sulphate B.P. and Armeen DM16D acetate both inhibit a specific coagulative factor produced by malignant tumours. This factor aids the invasiveness of tumours, and its inhibition is known to retard tumour growth.Protamine and Armeen both had a greater effect on an implanted subcutaneous mouse tumour, Sarcoma 180, at 9° to 10°C than at 24° to 25°C.

Zusammenfassung

Sowohl Protaminsulfat als auch Armeen DM16D Acetat hemmen einen spezifischen gerinnung verursachenden Faktor, der von malignen Tumoren gebildet wird. Dieser Faktor erleichtert das infiltierende Wachstum der Tumoren und seine Hemmung verzögert es. Die Wachstumshemmung von subkutan implantierten Sarcoma 180 Tumoren durch Protamin und Armeen war grösser in Mäusen in der Kälte bei 9° bis 10°C als bei 24° bis 25°C.

Resume

Le sulfate de protamine et l'acétate d'armeen DM16D sont les inhibiteurs d'un principe coagulant spécifique produit par les tumeurs malignes. Ce principe facilite le développement et l'infiltration de la tumeur dans les tissus et son inhibition les ralentit. L'action inhibitive de la protamine et de l'armeen sur des tumeurs (Sarcoma 180) implantées sous la peau de souris fut plus efficace au froid (9° à 10°C) que par 24° à 25°C.

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Authors and Affiliations

  1. Riker Laboratories, Tewin Road, Welwyn Garden City, England

    J. P. Austin & E. M. Glaser

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  1. J. P. Austin
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  2. E. M. Glaser
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Austin, J.P., Glaser, E.M. Enhancement of anti-tumour effect by cooling. Int J Biometeorol 13, 183–187 (1969). https://doi.org/10.1007/BF01552739

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  • DOI: https://doi.org/10.1007/BF01552739

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