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Analysis of Thy-1 variants of murine lymphoma cells

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Somatic Cell Genetics

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Abstract

Cells obtained from a radiation-induced T-cell lymphoma of BALB/c mice, RL♂-I, were adapted to long-term tissue culture. Clones of cells were obtained in soft agar and a clonally derived population studied for the frequency of mutation in the expression of the surface antigen Thy-1.2 (ØC 3H) by immunoselection. The mutation rate was 1.05–1.50× 10−6 per cell per generation. Antigenic and structural analysis of prototype positive and negative clones demonstrated clear differences between them.

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Authors and Affiliations

  1. Department of Medicine, New York University School of Medicine and Research Service of Manhattan Veteran's Administration Hospital, New York, New York

    J. N. Buxbaum & R. R. Szabadi

  2. Department of Pathology, New York University School of Medicine and Research Service of Manhattan Veteran's Administration Hospital, New York, New York

    R. S. Basch & R. R. Szabadi

Authors
  1. J. N. Buxbaum
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  2. R. S. Basch
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  3. R. R. Szabadi
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Buxbaum, J.N., Basch, R.S. & Szabadi, R.R. Analysis of Thy-1 variants of murine lymphoma cells. Somat Cell Mol Genet 3, 1–15 (1977). https://doi.org/10.1007/BF01550983

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  • DOI: https://doi.org/10.1007/BF01550983

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